I posted it to my mast cell groups...it was already up in 2 of them. In the neurological-psychiatric issues// mast cell group, we had someone saying she felt disappointed about
the article including DNRS as a treatment. For those who don't know, that is Dynamic Neural Retraining System. The other "brain retraining" that I have known people to do is Gupta's so-called amygdala retraining. Over the years I have seen some people have good success with each program, at both myPatientMatch and on FaceBook. 3 of my FB friends are doing it right now. It does not help everyone, including the person who wrote her objection to that part of the article. (I could be jumping to a conclusion, but it seems less helpful for people with a lot of health issues...which as I type that, that seems silly, because who in those groups does not have a lot of issues? Well I think perhaps it's harder for hEDS patients to get great success. I do recall that some for whom it does not work also have hEDS.)
I suppose on the surface, including DNRS in the article could be seen as once again implying things are "in your head", somatoform vs. physical. But two years ago I found some really interesting research. It is always amazing
(1) how fast the body communicates within itself and
(2) sets up warning and response systems.
I found this two years ago, and think It relates to the discussion.
There is a Pavlovian mast cell response.
During the 1890s Russian physiologist Ivan Pavlov was looking at salivation in dogs in response to being fed, when he noticed that his dogs would begin to salivate whenever he entered the room, even when he was not bringing them food. This is called a conditioned response, or Pavlovian response.
fyi: Mast cells release protease II (two)
Title:Pavlovian conditioning of rat mucosal mast cells to secrete rat mast cell protease II.
MacQueen et al.
Rats were injected with egg white ("albumin"), which caused release of mast cell mediators. This was paired with a simultaneous audiovisual cue.
After that, those same rats were given a re-exposure to only the audiovisual cue. When they measured protease II, they found that using just the cue caused a mast cell response. The released amount of protease was much the same amount as in a group that was injected again and simultaneously given the audiovisual cue. (There was another control group, as well.)https://www.ncbi.nlm.nih.gov/pubmed/2911721
I will make this as brief as I can.
I found that there was another study that pricked the skin of a real hand and histamine was applied and rubbed, and caused a skin reaction. A sham experiment was done with a rubber arm/hand, and the Title tells the story:
"The rubber hand illusion increases histamine reactivity in the real arm." The author is Barnsley. https://www.researchgate.net/publication/51863374_the_rubber_hand_illusion_increases_histamine_reactivity_in_the_real_arm
My theory is that perhaps either CRH or substance P release causes this. Certain actions (space flight, parachute jumping, restraint, anxiety will cause elevated SP levels in the brain. SP is a mast cell activator. But that might be completely wrong. I just like playing with ideas in my mind. It could be a neurotransmitter like histamine.
fyi for newbies. The neuropeptide Substance P has been measured in fibro studies of cerebral spinal fluid and muscles, and found to be higher in fibro. Also higher in ME/CFS. (The same goes for neuropeptide y.)
Just a little side note, a study postulates: "The results of the present study suggest that an individual's salivary oxytocin concentration can predict the extent to which the individual experiences the RHI [rubber hand illusion[; furthermore, oxytocin might modulate the sensation of body ownership.
Salivary Oxytocin Concentration Associates with the Subjective Feeling of Body Ownership during the Rubber Hand Illusion https://www.researchgate.net/publication/315970488_salivary_oxytocin_concentration_associates_with_the_subjective_feeling_of_body_ownership_during_the_rubber_hand_illusion
[accessed Jun 6, 2017].
I have done a little more reading on oxytocin...but this is long enough. Better not look for it in my notes.
Post Edited (Rockon) : 7/24/2019 10:52:15 PM (GMT-6)