Someone had mentioned this before with Sovaldi, but it ended up as more of a sidenote. I just came across it again with Olysio, so for safety's sake I thought I'd post it. This may be something they tell people on Olysio already, but just in case. It seems like good info, but if someone knows different, let me know and I will delete it.
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This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.
Very important. A change in your diet, medicine, or dosage may be necessary. Promptly consult your doctor or pharmacist.
How the interaction occurs:
Grapefruit juice may increase the amount of simeprevir in your blood.
What might happen:
When simeprevir is taken with grapefruit juice, the grapefruit juice may cause the simeprevir to build up in your body. This increased amount of simeprevir can have a greater effect of both desired and undesired effects.
What you should do about
While you are taking this medicine, you should avoid eating grapefruit or drinking grapefruit juice. You may choose an alternative citrus beverage (such as orange juice). In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juice you should discuss with your doctor the effects of grapefruit on the blood levels of this medicine. These effects can occur even if grapefruit is not consumed at the same time as the simprevir dose. This interaction may occur at any time in your treatment with simeprevir if grapefruit or grapefruit juice is consumed.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Olysio (simeprevir) US prescribing information. Janssen Products, LP November, 2013."www.webmd.com/drugs/drug-165474-Olysio+oral.aspx?drugid=165474&drugname=Olysio+oral&dmid=129&dmtitle=More%20significant&intrtype=FOOD&pagenumber=9