prednisone drop/another serious depression & mood swings

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Regular Member

Date Joined Aug 2006
Total Posts : 254
   Posted 12/20/2006 7:16 PM (GMT -7)   
<!-- Network content --><!--~-|**|PrettyHtmlStartT|**|-~--> It has been awhile since I have posted. I am

down to 12.5 mil of pred. having rapid mood swings, joint pain,
serious depression. I have no desire to do anything..

I'm doing better tonight, but yesterday was a difficult one. Mood
swings, stress, depression and just a doom and gloom was one of the
worst times since I stared posting. I have been pulling away from
everyone and have felt like running and hiding. I went back on the
mood stabilizer even though I do not like the side effects. I don't
seem to feel as tired as I wean off the pred. and the mental
confusion )frain fog) seems to have lifted some. But the stress of
Christmas, the depression and uncertaintly is before me. I am either
crying or mad.

I talked for a long time to my brother in CO. He is a therapist. That
helped me some. I have bi-polar 2 disorder, I'm not sure if anyone
else in the group understands anything about it or has it. It is a
dificult disease to manage. Mine is the rapid cycling and quick mood
changes, and major depression.
I was put on an additional mood stablizer when I went on the
prednisone. I hate the side effects of it (lithium) and have started
and stopped several times. But because of the mania that the
prednisone was causing and the the mental and emotional problems
associated with prednisone, my doctors thought it best. Before the
prednisone, even though I was very tired, At least I
felt stable in my mind.
Lately I have not, even on the medication. I am told it is the
prednisone withdrawl that is likely causing the depression and mood

I gave myself permission to rest all day today, not answer my phone,
have no one make any demands on me ..ect.. And I will continue to do
that to reduce the stress level until I feel that I can handle
outside things again. I have to do this for myself. I have to create
a safe place for me to be physically and mentally.

I do not know if I will celebrate Christmas. We may go away for a day
or so. And I may just visit my children and drop off
their gifts instead of taking it upon myself to do all that is
usually expected of me. Thanksgiving was very stressful with me
wanting to make "everything perfect" and I felt totally out of
So, I will simplify things this year by doing what I feel comfortable
doing and I will let the chips fall with my grown children with their
expectations of me.

I'm sorry if this sounds like a pity party, but it's just the way it
is. Does anyone in the group suffer from depression?

Blessings and Wellness to you all.
And holiday greetings.


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Veteran Member

Date Joined Mar 2006
Total Posts : 605
   Posted 12/22/2006 8:32 AM (GMT -7)   
sorry your going through a depression judy,,,,i suffer from depression though not for the same reasons as you. Im glad your allowing yourself time to feel better and blocking out the outside world for a while,,,but i hope that doesnt last long. as far as christmas goes, I know ppl get stressed out,but its not supposed to be a time of stress ,it should be a time of togetherness,and feeling love with your family and friends,,,im not sure what your childrens expectations would be of you ,,but mine are getting chili for christmas eve dinner:) easier for me to deal with,less dishes and they love it,,not to mention that they eat at other places and its something different for moms meal:) my kids enjoy my meals because they never know from one holiday to another what to expect from me. one year,,i had worked a lot of hours(boss was gone for a month) and i didnt have time to wrap my presents to my kids,so i just started throwing bags out of the bedroom! lol they will never forget mom winging bags to them from the bedroom door and it didnt take away from the Christmas spirit at all :) so maybe instead of "cancelling" Christmas festivities,,,make them easy and fun :) might make you feel better too,,hope today is better then yesterday for you ,,take care
Life should NOT be a journey to the grave with the intention of arriving safely in an attractive and well preserved body,but rather to skid in sideways,chocolate in one hand,wine in the other,body used up ,totally worn out and screaming"WOOOOHOO WHAT A RIDE!!!" 

Regular Member

Date Joined Dec 2005
Total Posts : 446
   Posted 12/28/2006 3:46 AM (GMT -7)   
Hi Judy,
I'm so sorry you are feeling so down.

I have been feeling sorry for myself, feeling depressed and crying again, and not wanting to see anyone but family. Even the "Happy" needles from Dr. Chen haven't helped this time.

Then I read of your problems, and I realise I have it good. My depression is mild compared to yours, but I do believe it's caused by weaning my Prednisone. I'm down to 10mg. You may have read my post earlier this month about being so miserable that I could not lower it more. I also know that I'm still grieving my sister who passed away last January. Christmas is so hard without departed loved ones.

Anyway, I hope you got through Christmas without too much extra stress. Mine was nice, with our little grand daughter, even though she's too young to understand. (18 weeks).

I'll be thinking of you and keeping you in my prayers.
Take care. Marg

Regular Member

Date Joined Jun 2012
Total Posts : 24
   Posted 6/8/2012 5:38 AM (GMT -7)   
This is my first (and hopefully only) encounter with this potent pyschoactive drug. I had an unexplained allergic reaction, started to swell in the throat. So I went to the ER and was giving a steroid injection in my butt cheek. Hurt like holy hell. Then was given a 40mg a day prescription of prednisone for 5 days. Today is day two of insantiy!

I'm 20 years old and have been on antidepressants for a few years, not for any bi-polar tendencies, just typical depression. I was totally caught off guard with no warning about the side effects of prednisone. A few hours later, this all happening while I was alone, I became suicidally depressed, weeping for no reason, wanting to die and hurt myself. Then I swung into a manic, paranoid, wired and confused state I haven't encountered for years. I definitely liken the experience to amphetamine psychosis. Minor visual hallucinations (blue flashing lights and motions unexplained), and talking and whining to myself, madness! Shakiness and twitching ensued. My jaw became tight and I chewed and gurned my teeth.

I thought it was a great idea to jump in the car at 2.00am to buy some hair dye, as I was apparently delusional and out of touch with reality. Drove around lost and confused for 45mins in circles. It was like having a psychotic breakdown! I looked like I was twicking on meth. I could have seriously injured myself or another, as I was a danger on the road. Got home (eventually) and cried some more. Then swung back to manic, dyed my hair and cut it and put on make up at 3am. Insomnia. Aches and pains my body hurt like I was having withdrawls. My eyes couldn't focus and my brain was in a stupor. It brought back my dermatillomania (I was scratching and itching my face til it bled). Then I was angry, irritable and irrational at my mother and my poor cat through no fault of their own.

The next day I started to research, and found this blog. The experience was very scary and frightening. I can deal with the acne, hunger, pains and all physical symptoms, but the psychological and emotional rollercoaster I couldn't handle alone. I told my mother and now she is helping me through my medically induced insanity. If I'd known earlier the effects of prednisone I would have at least asked to be watched for such disturbances.

Elite Member

Date Joined Jul 2005
Total Posts : 12014
   Posted 6/8/2012 6:28 AM (GMT -7)   
Hi, Bethlemong. Welcome to the Hepatitis Forum. I see you are no stranger to HW. I had a similar, though milder, experience with Prednisone back in the 70s. I had auditory and visual hallucinations for 3 days, along with insomnia. I finally went to the ER and was given Trazodone for a week. Because of this experience, I was terrified of ever taking it again. However, when I had a liver transplant last Oct., I was put on Pred. for 4 mos. I had some hallucinations and insomina for 5 days, but as the dose tapered, the side effects went away. It really is an awful drug. It's not really an allergy, but rather a psychotic reaction.

Normally, I would ask you to start a new thread, but since it seems you don't have liver problems I will simply thank you for your input. Feel better.

Forum moderator - Hepatitis

"But that was yesterday, and I was a different person then."

Lewis Carroll, Alice in Wonderland

Liver transplant recipient, Oct. 27, 2011, at Mayo Hospital, Jacksonville, FL
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