There have been people on here before who have taken as many as 6 Welchols a day, so it's not entirely unheard of to have to take a lot. I take mine first thing in the morning, then typically wait a couple of hours to eat, as I am most likely to have stomach problems in the morning. I take two right now, but if I have more than a couple of bowel movements in the morning, I usually take a third to stop them. I take two calcium pills before bed with a multi-vitamin. The Welchol interferes with absorption of a number of things, including fat soluable vitamins. After being on it for several years, I developed a constant malaise and I was almost constantly sick with every weird thing going around. When I started on the vitamins, the malaise disappeared and I don't get sick as often. Because the Welchol interferes with not only natural vitamin absorption, but the pill kind too, I take the multi-vitamin and calcium at night so I am as far opposite the Welchol dose as possible, so I get the most benefit from both. Also, never hurts to put some calcium in the gut before shutting it down for the night. Again, my worst time is first thing in the morning.
Do you do anything to limit your diet? Even with the Welchol, there are things I can't have. Namely sugar alcohols (found in sugar-free products), caffeine, fruit juice, raw apples, and anything commercially deep fried. Milk is a bit touchy; I have to be careful how much of it I consume at one time.