I've had IBS-C for 12 years. I was on Zelnorm until they pulled it off the market, and for the past 8 months have been on Amitiza. I'd say it works about 50% of the time. Looking back I feel like it makes my bloating worse, even when it does work. And when it doesn't produce results, I feel just horrible. The biggest side effect I've noticed that hasn't gone away is that my body temp has gone up. I'm always hot. I didn't use to be this way. I don't have hot flashes - just always hot, ever since I starting taking this stuff. Anyone else experience this?? I'm starting to think it isn't worth the expense or misery of taking it anymore.