Sorry this is the IBS Sufferer. I am new so I was not sure how to use this Iam a 33 year old female who has been suffering from this so called disease of which they can not even see since the birth of my son. In my gut, I know it started after my C-Section. I mean after all your insides are taken out. Any way, this disease has been a way of life for me. I have been to so many doctors and have just as much medication as MJ was getting. O.K i am exaggerating a tad. I have had the colonoscopy years back. They found of course nothing. They gave me Donotal, Librax, told me to drink Citrucel, Metamucil. What did this do, give more gas and made me more bloated. So they moved on to Zoloft. Oh yea that is the latesrt SSRI's help IBS yea right. The Zoloft might be helping the depression I have due to the chronic IBS. Yes that makes more sense. How about all of you who say anxiety is the trigger, some Xanax please. So yes that is the only plus in all of this. Added to my medication regimen: Xanax. Then they tell you to try to reduce stress levels because that is where all my stress goes to my gut. Well, somebody please try to show me how to do that with two small children, a full time job, a house oh and yes suddenly loosing your father less than a year ago to blood cancer. O.K so thats not possible. So for all you suffers. It became a way of life . Glycolax when I could not go, lots of time in the bathroom. Praying that today I would go so I would feel less bloated and less gassy. Probiotices I thought were going to be it for me. Yup how did you guess, nothing. O.K i will admit I probably got frustrated before even giving them a shot. As for Zelnorm, tried it when it first came out. All it gave me was cramps and diarrhea and gas. I thought that was what it was suppose to be targeting. So then I went through my thats it I am not going to eat phase. I lost 10 pounds. I started hating food. What a way to live right? Im italian so yes baked iti, lasagna, meatballs, calamari, boy was I missing out. I would take my prescribed drugs when I felt like itnot as prescribed. Ive tried Gas X- IBS meds (over the counter) nothing nothing nothing. So just recently I went to the doctor AGAIN to get my prescriptions filled. Not for my stomach but anxiety. Hey what kind of Doctor are you anyway? Guess what he gave me Amitiza. That is how I got on this site. I was trying to do research on this drug. This is my second day on it. So far alittle headache, not much nauseau yet. No BMS yet either. Who knows if it will work. At this point even the comments about this drug don't scare me. Im so desperate I will try anything. Who knows maybe it will work, maybe not. Any relief would be helpful. Oh yea the colon cleanses. In all fairness, I got fed up with Dual Action Cleanse It caused even more gas. Maybe I should have continued through. At this point who knows. Please reply. Will keep you all informed with th AMITIzA!!!! I welcome all replies. I don't feel as alone after being on this site. Good luck to all.