For those of you with a lot of problems that seem worse than "usual" IBS and have no other answer, make sure you get tested for C. difficile. People who take certain heartburn medicines are more likely to contract it, in addition to people who have been on antibiotics. And now some people seem to be getting it for no reason at all. They are starting to see more virulent strains that are attacking healthier people and that are harder to get rid of.