Well i've just popped 3 seirogans just for curiosity. I've been having D + loose stools all week, so if i get constipated for the next couple of days i'll let you know. Tell you what though, these non-sugar seirogan pills reak.. i popped one an hour ago, and i can still smell it on my breath.
During my research into seirogan, it showed that the electrical signals which can cause diahorrea were inhibited and that seirogan does contain a mild antibiotic. (do a google, it appeared in a medical journal) i'll try to dig it up again.
Anyhow. Herbal therapy isn't all snake oil stuff, the reason it doesn't get pushed as much in the western world is because there are no big name companies like Roche etc marketing and developing it.
*edit : here are some medical articles about seirogan if you have time, go have a read.
1. Cook GC. Diarrhea disease: a worldwide problem. J Royal Soc Med 1998;91:192-4.
2. Guerrant RL, Moore RA, Kirschenfeld P, Sande M. Role of toxigenic and invasive bacteria in acute diarrhea of childhood. N Engl J Med 1975;293:567-72.
3. Richards L, Claeson M, Pierce NF. Management of acute diarrhea in children: lessons learned. Pediatr Infect Dis J 1993;12:5-9.
4. Garthwright WE, Archer DL, Kvenberg JE. Estimates of incidence and cost of intestinal infectious diseases in the United States. Public Health Rep 1988;103:107-15.
5. Steffen R. Epidemiologic studies of travelers' diarrhea, severe gastrointestinal infections, and cholera. Rev Infect Dis 1986;8(suppl 2):122-30.
6. Ryan ET, Kain KC. Health advice and immunizations for travelers. N Engl J Med 2000;342:1716-25.
7. Guerrant RL, Bobak DA. Nausea, vomiting, and noninflammatory diarrhea. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and practice of infectious diseases. New York: Churchill Livingstone, 1995:965-73.
8. Fine KD, Krejs GJ, Fortran JS. Diarrhea. In: Sleisenger MH, Fortran JS, eds. Gastrointestinal disease: pathophysiology, diagnosis, management. Philadelphia: WB Saunders, 1998:1043-72.
9. Anonymous. Physicians' desk reference. 54th ed. Montvale, NJ: Medical Economics Company, 2000:2923-4.
10. Gattuso JM, Kamm MA. Adverse effects of drugs used in the management of constipation and diarrhoea. Drug Saf 1994;10:47-65.
11. Haller JS. Creosote: a short history of its medicinal uses. Conn Med 1990;54:502-7.
12. Ogata N, Baba T. Analysis of beech wood creosote by gas chromatography-mass spectrometry and high performance liquid chromatography. Res Commun Chem Pathol Pharmacol 1989;66:411-23.
13. Kuge T, Shibata T, Willett MS, Turck P, Traul KA. Lack of oncogenicity of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, in Sprague-Dawley rats. Int J Toxicol 2001;20:297-305.
14. Greenwood-Van Meerveld B, Tyler K, Kuge T, Ogata N. Anti-diarrhoeal effects of Seirogan in the rat small intestine and colon examined in vitro. Aliment Pharmacol Ther 1999;13:97-102.
15. Greenwood-Van Meerveld B, Tyler KR, Venkova K, Kuge, T. Comparison of the antidiarrheal effects of wood creosote and loperamide in the rat jejunum and colon in vitro. Biol Pharm Bull 2000;23:952-6.
16. Ogata N, Shibata T. Antidiarrheal activity of wood creosote: inhibition of muscle contraction and enterotoxin-induced fluid secretion in rabbit small intestine. Pharmacology 2001;62:181-7.
17. Taiko Pharmaceutical Company, Ltd. Seirogen product labeling. Osaka, Japan; 2000.
18. Taiko Pharmaceutical Company, Ltd. Data on file. Osaka, Japan; 2002.
19. Kuge T, Shibata T, Willett MS. Multiple dose escalation, safety and tolerability study of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, in healthy subjects. J Clin Pharmacol 2003;43:284-90.
20. Ogata N, Matsushima N, Shibata T. Pharmacokinetics of wood creosote: glucuronic acid and sulfate conjugation of phenolic compounds. Pharmacology 1995;51:195-204.