Drugs that control IBS-D

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

New Member

Date Joined Nov 2006
Total Posts : 5
   Posted 11/17/2006 3:05 PM (GMT -7)   
My doctor of many years experience in the UK prescribes Nortriptyline and Fluphenzanine Hydrochloride for my IBS. They certainly work and in particular control urgency(the ultra embarassing bit of having IBS).
Today when I went to the young recently qualified pharmicist to renew my prescription, she was very concerned that these two drugs should not be taken in combination. In fact she has made a point of registering her concern directly with my doctor.
Does anyone have an opinion?

Regular Member

Date Joined Jun 2006
Total Posts : 41
   Posted 11/21/2006 1:43 PM (GMT -7)   
You may want to wait to hear back from your doctor before taking both of them?  SOmetimes the pharmacist is more skilled in knowing the interactions of med's.  Call your doctor and make sure. 

New Member

Date Joined Nov 2006
Total Posts : 5
   Posted 11/21/2006 2:01 PM (GMT -7)   
Thanks for the advice and I shall do what you suggest

Veteran Member

Date Joined Jul 2005
Total Posts : 2433
   Posted 11/21/2006 2:56 PM (GMT -7)   
I just wanted to share a great website I use for drug interactions:

Here is what it said about these two drugs:

Drug-Drug Interactions

nortriptyline and fluphe****ne (moderate Drug-Drug interaction)

Coadministration of a phenothiazine with a tricyclic antidepressant (TCA) may result in elevated plasma concentrations of one or both drugs as well as additive adverse effects. Most phenothiazines and TCAs have been found to undergo metabolism by CYP450 2D6, thus competitive inhibition of the enzyme may occur when more than one of these agents are administered. Although these drugs have been used together clinically, the possibility of increased risk of serious adverse effects such as central nervous system depression, tardive dyskinesia, hypotension, and prolongation of the QT interval should be considered, as many of these agents alone can and have produced these effects. In addition, excessive anticholinergic effects may occur in combination use, which can result in paralytic ileus, hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. Peripheral symptoms of anticholinergic intoxication commonly include mydriasis, blurred vision, flushed face, fever, dry skin and mucous membranes, tachycardia, urinary retention, and constipation. Central symptoms may include memory loss, disorientation, incoherence, hallucinations, psychosis, delirium, hyperactivity, twitching or jerking movements, stereotypy, and seizures.

Concurrent use of phenothiazines and TCAs should be approached with caution, particularly in the elderly and those with underlying organic brain disease, who tend to be more sensitive to the central anticholinergic effects of these drugs and in whom toxicity symptoms may be easily overlooked. Patients should be advised to notify their physician promptly if they experience potential symptoms of anticholinergic intoxication (e.g., abdominal pain, fever, heat intolerance, blurred vision, confusion, hallucinations) or cardiovascular toxicity (e.g., dizziness, palpitations, arrhythmias, syncope). Ambulatory patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them. A dosage reduction in one or both drugs may be necessary if excessive adverse effects develop.

Drug-Food Interactions

No interactions were found.
If you require further information, please consult with your doctor or pharmacist.

Ali - All I did was make your link linkable.  -- Lil  tongue

Post Edited By Moderator (7Lil) : 11/21/2006 4:54:35 PM (GMT-7)

Veteran Member

Date Joined Jul 2005
Total Posts : 2433
   Posted 11/21/2006 2:57 PM (GMT -7)   
just so you know, the **** is because the site won't allow you to type out n-a-z-i (which is a part of the drug name!)
Co-mod for HIV/AIDS 
"The pessimist sees difficulty in every opportunity. The optimist sees the opportunity in every difficulty."

New Topic Post Reply Printable Version
Forum Information
Currently it is Wednesday, December 13, 2017 9:43 PM (GMT -7)
There are a total of 2,905,166 posts in 318,836 threads.
View Active Threads

Who's Online
This forum has 158202 registered members. Please welcome our newest member, Tweetybird1969.
294 Guest(s), 6 Registered Member(s) are currently online.  Details
DBwithUC, ericleer, Girlie, ByHisGrace, Tweetybird1969, sillyliquid