Yours is a really tough situation. One thing that jumped out at me is that the Prednisone worked for you. Prednisone is an immune suppressant so it would not affect your IBS either way, if it is/was IBS. It helped calm down the inflammation which appears to be an immune response. Given that though does not necessarily mean IBD. There are many other causes of over active immune system or autoimmunity. IBD is just one (2 if you count both Crohn's and UC). I was given the UC diagnosis a couple of years ago because I had ulceration and inflammation in my colon. Like you, I was put on a short dose of pred and UC maintenance meds which helped and worked. My last two follow up scopes indicated NO ulceration let alone inflammation, I was taken off the meds and still was fine... thus the UC diagnosis was taken away. In the midst of all this time, it was discovered that I had a connective tissue disease, UCTD (or early lupus). Everyone of my docs now are believing that it probably was the Lupus that attacked my colon (Lupus can attack any organ in your body causing inflammation).
Now I'm not saying that my story can anyway be related to yours however it points out that things aren't always this or that. The frustration in getting any kind of answers or diagnosis I can truly relate to and seeing that you have gone a long time with this (so glad you had a long remission), my heart truly goes out to you.
Inflammation and blood can also be caused by food poisoning and other type of problems. It really pays off to get a full workup and really push your docs with this. I also agree with softy that a pill camera test is a good idea.
I sure hope you can get some answers soon, please keep us updated.
Co-Moderator ~ IBS Forum
Co-Moderator ~ Lupus Forum
Dx: IBS 1989, Diverticulosis 2004, Idiopathic Acute Colitis 2006, UCTD 2007
Meds: Plaquenil 400mg, Chlorzoxazone 500mg, Lyrica 50mg, Protonix 40mg, Lodine XL 1000mg, Klonopin PRN, Miralax 17g, Supplements