Imuran vs Prednisone vs Methodrexate update

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Regular Member

Date Joined May 2007
Total Posts : 482
   Posted 1/15/2008 8:25 PM (GMT -6)   
Hello, everyone, again! A while back I had posted that rheumy was thinking of starting Imuran. Everyone was very helpful and I really appreciate it. I ended up on a quick pred burst (wow was that great).
So, Rheumy did some blood work and we decided to give Imuran a try. Yesterday was day 10. Oh man, did I get sick. Temp up to 104.2, face, throat and neck swelled, and I couldn't catch my breath. Called rheumy who sent me in for a flu test, once flu was ruled out, he took me off the Imuran. Said I had a delayed, but very SEVERE reaction to the drug. Apparently, some people just can't tolerate it and I seem to be one of them. Today I am somewhat better (and full of Benadryl and Tylenal). I have to go back to the rheumy next week. I've had reactions before, but I don't ever remember spiking such a high fever! I think I really scared my DH! I honestly don't remember most of yesterday, but I guess I was pretty bad. I know that I will deal with the lupus symptoms before I'll ever try Imuran, again!
Hope everyone is having a good day!
Take care,

Dx: Lupus, sjogren's, celiac, severe allergies.
Daily Meds: Plaquenil, Imuran, Zyrtec, Prilosec, Nasacort, Prozac.
As Needed Meds: Epinephrine, Benadryl, Proventil, Xopenex, Tylenal, Prednisone.

Veteran Member

Date Joined Jan 2005
Total Posts : 8616
   Posted 1/15/2008 9:48 PM (GMT -6)   
Oh Fran . . . glad you got that figured out . . . must have been very scary!! I hope they find another med that will help you. So sorry sis!


In His Grip

AlwaysRosie           "We can't control the waves, but we can learn how to surf!!"

Psalms 139

Co-Moderator - Lupus Forum

UCTD, Hashimotos, Inflammatory Bowel, Inflammatory Arthritis

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Regular Member

Date Joined Dec 2004
Total Posts : 121
   Posted 1/16/2008 9:13 AM (GMT -6)   

Hi Fran,

I had the same kind of thing happen to me with Imuran.  I tolerated it ok for a week or so, then started to develop a low grade temp, then started with back pain.  The back pain got worse and worse, thought it might be kidney pain, finally went in to the doc and he wanted to do a lumbar puncture.  He was thinking that the temp along with the back pain (to the point I was having trouble walking) might possibly be spinal meningitis.  I asked him to talk to my nephrologist first and the first thing he did was tell him to take me off the Imuran.  Within 2 days the symptoms were gone.  It might be that Imuran is one of those drugs that take a little bit to develop a reaction to.  I'm glad they figured it out with you too!


Barbara Lee
Veteran Member

Date Joined Sep 2003
Total Posts : 2889
   Posted 1/16/2008 12:02 PM (GMT -6)   
Hi Fran:

I got sick on Imuran too. I ended up with Meningitis and a temp of 104.0 too. You're very luck they caught it in time. I'm currently taking Methotrexate and Humira. I'm not sure about the Humira but the Methotrexate does make my life bit better. You may want to consider trying it.

Wishing you the best.

dx fibro, SLE, glaucoma, cateracts, bells palsy, depression, migraine headaches, gastreopaersis, chronic anemia, RA,MDS (Blood Cancer). Tons of meds.

Regular Member

Date Joined May 2007
Total Posts : 482
   Posted 1/16/2008 10:01 PM (GMT -6)   
Always Rosie, Lori, and Barbara,
Thank you so much for your replies.
I really appreciate it!
What's really strange is that, while it took 10 days or so for the reaction to occur, when it did, it was so fast!
Lori and Barbara - I am so sorry that you know EXACTLY what I was talking about, but so grateful that I am not the only one. I know it's strange, but, for some reason, I don't feel quite as weird about the whole thing, now. LOL
I have now missed 5 doses of Imuran and I am well on my way back to normal (well, for me, anyways).
There are still some shooting pains from behind my eyes straight down my neck into my back. But they are becoming less severe and occurring less often. Thank God!
Again, I thank you!
Take care,

Dx: Lupus, sjogren's, celiac, severe allergies.
Daily Meds: Plaquenil, Imuran, Zyrtec, Prilosec, Nasacort, Prozac.
As Needed Meds: Epinephrine, Benadryl, Proventil, Xopenex, Tylenal, Prednisone.

Veteran Member

Date Joined Sep 2005
Total Posts : 2573
   Posted 1/18/2008 5:59 PM (GMT -6)   
I am so sorry you can't take Imuran. I am terrified of the day my rheumy suggests MTX
Dx:fibromyalgia 2002, systematic lupus 2005, rheumatoid arthritis 2006, PTSD 2007, multiple allergies 2005, migraine, compression fractures T11 & T12, Sjögren's, pregnant due May 2008
Tx: plaquenil, Enbrel, Darvocet, Singulair, Flexeril, Baby Asprin,Prednisone, Imuran, Procardia

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