Congratulations on your first dose of mtx! I know it was a big decision. It was for me too--it did take a bit longer,though, for the drug to actually kick in. For me, it took about 2 months or so to feel different. I experienced nausea and fatigue for the first few doses of mtx (just for a few days after the weekly dose), but after that, nothing. No nausea, no fatigue. I have no side effects whatsoever from the mtx. I do take the folic acid faithfully. Even when I run out of the prescription folic acid (which is a higher dose), I keep generic OTC folic acid around to supplement until the prescription is filled. My rheumy told me you can't take too much folic acid.
Overall, mtx has been a great drug for me, and I hope it is for you as well.
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Methotrexate, nexium, tramadol, nasonex,Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan, zyrtec, zegerid, aciphex