Question on Methotrexate

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Regular Member

Date Joined Oct 2007
Total Posts : 100
   Posted 3/6/2008 8:17 PM (GMT -6)   
Wondering what dosage of Methotrexate every one is on.
I'm currently on 15 mg/week.  However my rheumy said if I have a hard time getting off of prednisone, he can up my methotrexate because I'm not yet at the maximum dosage.
SLE: 07/07, Irritable Bowel Syndrome, migraines
400 mg. plaquenil, 9 mg. prednisone, 2400 mg. ibuprofin, 15 mg. methotrexate, folic acid, asacol, caltrate-D, wellbutrin, paxil, lybrel, Keppra (as needed)

Regular Member

Date Joined Jan 2006
Total Posts : 90
   Posted 3/6/2008 9:04 PM (GMT -6)   

I am currently on 10 mg of injectable mtx a week, and the most I could tolerate was 15. It helped me wean off of pred. and I now only use prednisone when I am flaring. I unfortunately cannot tolerate more!

Hope this helps,


Veteran Member

Date Joined Oct 2004
Total Posts : 2244
   Posted 3/6/2008 9:18 PM (GMT -6)   
I am on 7.5 mg, I just started taking it about 3 weeks ago. I am also on 100mg of Imuran. I hope it works well for you so you can come off pred.

Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Hashimoto's 1999, Celiac Disease (AKA: gluten sensitivity) 2003, Raynaud's 2004, Lupus 2005 and Sjogrens 2006
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Lortab (as needed), Magnesium Citrate and magic mouthwash (as needed for mouthsores)

Veteran Member

Date Joined Jan 2005
Total Posts : 8616
   Posted 3/7/2008 10:34 AM (GMT -6)   

I started at 15 mg and upped to 20mg. I took mtx for about a year - over a year ago and did quite well on it. The biggest thing I noticed was that the fatigue lifted quite a bit.


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Regular Member

Date Joined Oct 2005
Total Posts : 251
   Posted 3/7/2008 11:01 AM (GMT -6)   
I'm at 15mgs too. My liver enzymes have jumped up a couple of times so my Rheumy doesn't want to increase it any further and I'm doing okay at 15mg anyway.
SLE diagnosis 10/05 now changed to RA 3/06, Endometriosis 5/05, PCOS 1990
Meds: Metformin ER 1500mg (PCOS); Loestrin BCPs (Endo); Methotrexate 15mg (RA); Metanx 5mg (RA); Orencia 750mgs (RA); Lunesta 2mg (as needed); Prevacid

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