I'm probably not going to remember this accurately but this is what my Rheumy told me when my ANA was rising on Remicade. That Remicade and Enbrel are made from mouse proteins? and the body starts making antibodies against those proteins because they don't recongnize them thus causing Lupus to flare or cause drug-induced Lupus. Humira is made of human proteins and therefore doesn't have this effect. I'm guessing this is why they have Barbara on Humira instead of the other TNFs.
SLE diagnosis 10/05 now changed to RA 3/06, Endometriosis 5/05, PCOS 1990
Meds: Metformin ER 1500mg (PCOS); Loestrin BCPs (Endo); Methotrexate 15mg (RA); Metanx 5mg (RA); Orencia 750mgs (RA); Lunesta 2mg (as needed); Prevacid