I got my labs from Mayo and I'm really glad they did my labs and ordered the right things it seems. They are much more sensitive than what the regular labs are.
The question I have is that I have the following antibodies present, in my blood:
ss-dna antibody, ELISA 41
ANA mildly elevated
SSB/RO < 0.2
Ab Liver/Kidney Microsome Ty 1 1.5
Antismooth Muscle Antibody NEG
Phospholipid Ab IgM serum < 4.0
Phospholipid Ab IgG serum < 4.0
Cytoplasmic neutrophil p-ANCA POS
AMA/M2 < 0.1
All of these levels (except the P-ANCA) fall below what would be considered a positive reaction, but are present, though not in high enough quantity to be considered positive by current standards. Except for the Antismooth Muscle Antibody which was clearly negative, all the rest are marked with a special mark and listed below, I guess as something to watch.
My question is, isn't the fact that I have these antibodies at all a sign that I have, or did have, or may be developing full-blown autoimmune disease?
I'm just wondering because my family has asked and it seems odd that one was clearly NEG while the others were not clearly negative, just low.
It makes me wonder about people with negative labs, who may have these antibodies, but not in high enough quantity to be considered a positive result at the time tested.
I also wondered what ss-DNA is vs. ds-DNA and what the difference is in terms of illness.
Hopefully this will help my doctors to see that something is happening. I also wonder if the plaquenil and pred tapers are the reasons why these might be low but present since all my inflammatory markers right now are in the normal ranges, which is great.
Thanks for any help you can give. Also, the doc recommended I up my plaquenil back to 400 a day for the stiff skin in the hand and finger and it already seems to helping some, though my forearm is shot. Anyone who wonders if it's worth a try, it's been over a year and its finally really working and it does make a great difference in some people.
Love to you all.
--Sometimes I think the surest sign that intelligent life exists elsewhere in the universe is that none of it has tried to contact us. Bill Watterson (1958-) cartoonist "Calvin and Hobbes"
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy, GI nightmare
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Detrol, Klonopin, Ultram, Vicodin, Restasis, Albuterol, steroid injections and pred prn