methotrexate and remission

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Regular Member

Date Joined Aug 2007
Total Posts : 206
   Posted 5/26/2008 10:04 PM (GMT -6)   
Has anyone here gone into remission with the use of methotrexate?  That last time I was at my rhuemy he told me to back off of my dose by 5 mg.  This will take place for the next 3 months until I see him again.  I am with the understanding that we will know if I am starting remission by backing off on the dose and if my symptoms do not return we assume I'm in good shape.  Also, I was recently told by a friend that taking folic acid on the same day as your methotrexate can block the meth from working.  She is on it as well and her dr said not to take it the same day as meth.  I have tried this only to wake with mouth sores for the next few days.  They aren't terrible, but they do get irritating and a little painful. 
I guess my question is what do I expect in the next few months while backing off the meth-and what do I expect with my remission.  My rhuemy can't answer this because he's doesn't experience Lupus the way we do. 
Also, will the fatigue go away some more while decreasing the methotrexate doses?
Thanks everybody!
"Challenges make you discover things about yourself you never really knew."
SLE and Class II Lupus Nephritis

Veteran Member

Date Joined Sep 2005
Total Posts : 2573
   Posted 5/26/2008 10:34 PM (GMT -6)   
I have never been on methotrexate, I stayed on my meds when I got my remission because it was the meds that put me in remission. I wish I could help but would love to know how it goes for you.
Dx:fibromyalgia 2002, systematic lupus 2005- definate CNS involvement dxed late 2005, psoriasis 2006, rheumatoid arthritis 2006, PTSD 2007, multiple allergies 2005, migraine, compression fractures T11 & T12, Sj√∂gren's, damaged periphrial nerves 2007,
Tx: plaquenil, Enbrel, Darvocet, Singulair, Flexeril, Baby Asprin, Imuran, Procardia, Prilosec

Veteran Member

Date Joined Dec 2007
Total Posts : 2113
   Posted 5/27/2008 7:59 PM (GMT -6)   
I take the folic acid every day. I also upped my folic acid dose to 3 mgs without asking my doc. I told her about it today and told her it took away all of my fatigue-so she wrote me a script for 3 mgs.
I had always heard that mtx does not induce sustainable remission that within months of stopping all symptoms would return. Maybe your doctor knows something I don't.

Veteran Member

Date Joined Oct 2004
Total Posts : 2244
   Posted 5/27/2008 9:31 PM (GMT -6)   
I take folic acid every day to keep mouth sores away, I started this long before taking MTX. I usually take 3 mg a day but doc has given me permission to take up to 5 mg, whatever my magic number is to prevent the mouth sores. I started MTX in the middle of Feb and feel no where near remission. I am on a lot of other meds too and whenever we start taking one away, like most recently trying to take me off Plaq, it was within a couple of weeks I was in a terrible flare, I hurt in places I didn't know existed, it was a little scary.

Take care and keep us updated on how you are doing.

Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Hashimoto's, Celiac Disease, Raynaud's, Lupus and Sjogrens
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Lortab (as needed) and magic mouthwash (for mouth sores)

Regular Member

Date Joined Mar 2008
Total Posts : 110
   Posted 5/28/2008 7:02 AM (GMT -6)   
I take folic acid everyday with my metho. My doctor has never said anything about not taking it on the same day. Actually, he had me start taking it a week before I started taking the mtx so that it could build up in my system.

dix: lupus sle Jan. '99, hypo-thyroid Mar. '06
rx: pred. 5mg/day, plaquenil 200mg/day, levothyroxine .112mg/day, premarin .45mg/day
wife, mother of three

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