I took plaquenil for a couple of years and it never did anything for me at all. Of course, I also take enbrel and mtx. My rheumy took me off the plaquenil, but told me to phase out and not go cold turkey. I phased it out over a couple of months and I haven't had any problems yet. Been without it for 6+ months now.
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Methotrexate, nexium, tramadol, nasonex,Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan, zyrtec, zegerid, aciphex