I've only been on prednisone therapy once, but it was a doozy of a dose. I was started on 80 mg, and instructed to taper over a week's period. I believe the last two days was 20mg, and then down to nothing. It was too much for my system. I believe my adrenal glands were having difficulties. I lost 10 pounds off the bat (8 of which I had gained in the brief time I was on the prednisone), and I remember being extremely fatigued and thirsty beyond reason. I couldn't drink enough water (which is very unlike me). I was starting to get a little worried about it, but after about 3 or 4 days, things started calming down again. The take home point is that prednisone is a very difficult drug to come off of. And I believe it needs to be done very very slowly. Also, some people are more sensitive to it than others. The doctor who prescribed it to me (not my rheumy) obviously felt that it was safe. My rheumy was horrified that I was on such a high dose (I don't think he ever would have prescribed that high a dose--I was flying). Some people may have been able to handle it? I would taper very very slowly. And know that if you want it to happen and work towards it, then eventually you'll be done with it.
Best of luck to you,
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Methotrexate, nexium, tramadol, nasonex,Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan, zyrtec, zegerid, aciphex