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Regular Member

Date Joined Mar 2008
Total Posts : 75
   Posted 8/15/2008 12:55 AM (GMT -6)   
I finally got into see my new pcp and get a second opinion on my positive ANA. They drew the blood on Tuesday and called to let me know that my results were in today. I went down there and my positive ANA is now Negative. All of my other labs look great and I again look like a head case. The new pcp is still in the process of getting the other labs from my old pcp that found the positive ANA. The only other thing is maybe i got a "false positive" the first time but what causes a false ANA positive? Do you have to be in a flare to have a positive ANA?? I am now extremely frustrated and feel like the rug has been yanked out from under me once again cry . I know that some people with lupus never have a positive ANA but what would make an ANA just come and go?? Isn't either you got it or you don't?? Any advice would be great.

Veteran Member

Date Joined Dec 2006
Total Posts : 2818
   Posted 8/15/2008 8:16 AM (GMT -6)   

((((((Natalie))))))), I'm sorry you have to go through this. I don't think there is a person here who doesn't understand what you are feeling. It gets really frustrating. Just about the time you think you got it figured out everything changes. As for the ANA, I am not sure why it changes but yes somtimes people have poss. and some time some people have neg. Mine has always been possitive but I know people here who have lupus that have never had a possitive ANA. Just try not to read to much into one test. I have never been diagnoised and my ANA is always around 1:2560! You'd think that high somthing would jump out but nope no answers yet. The best thing you can do is keep track of everything that changes in your body. Aches pain fever joint swelling, hair falling out. rash. mouth sores. The best you can hope for is to be treated for the symptoms even if you never have a yes or no answer. If your doctor doesn't treat your symptoms then you need a new doctor. If your doctor wants to blow things off because you get a neg. ANA you may want to see somone else. Don't give up or feel like a nut case. We all have gone thru that one too. Oh no you do not have to be in a flare to have a possitive ANA. Mine never really changes by much weather I am sick or not. If anything your SED rate would change.

Hang in there sweetie. You are no more of a head case then I am. turn (i'm a bad example)



Possible scleroderma.  stage 4 COPD,  Osteoporosis,osteoarthritis
Prednisone,plaquanil400mg,azythromyacin,vicodin 4x5mg,Evista60mg, Effexor 150mg,Xanax 1.0 x3,Singular,nitro spray, spirivia,aciphex,lasix,inderal,pot.chlor.,B12 
I will never leave you nor forsake you!

Veteran Member

Date Joined Jan 2005
Total Posts : 8616
   Posted 8/16/2008 4:44 AM (GMT -6)   
((((((((( Natalie )))))))))) I sure don't know how to answer your questions. Lots here have gone negative after some pretty high positives. Some meds can make you go negative. There are also meds that can cause "drug induced lupus" but I don't know of any that cause an actual false positive.

Diagnosis for the autoimmune diseases can be so tricky and can take a lot of time. Many of us have been diagnosed and then undiagnosed !!!

Just wanted to send you a big hug.


In His Grip

AlwaysRosie           "We can't control the waves, but we can learn how to surf!!"

Psalms 139

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UCTD, Inflammatory Arthritis, Diverticulosis, (recent dx - Sjogrens, Crohn’s 4/08)

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