Doctors are currently relying heavily on the fact that genetics cause disease. This is false. Infectious agents cause disease, period. Genetics will dictate how we react to an infectious agent. Our genome dictates our behaviour, at the cellular level. Certain alleles will be active within a cell so the cell will be able to perform whatever its function is, the other alleles will be inactive. Our genome is a build up of hereditary traits that dictate are cellular behaviour. Nematode worms have been with our species for a very long time, it is a plague, we cannot shake it, because we do not have the medicine to kill them. According to internal medicine texts they can kill the worm. According to field reports from doctors who treat filariasis they can kill the microfilaria but not the worm, it is also believed this same medicine sterilizes the female worms. Because of this longevity of infection our species will have diversity of naturally implemented genetic code for fighting the parasite. Some people are allergic to ragweed pollen. Some where down that persons genetic tree, someone inhaled some pollen that was more than ragweed. It was carrying something infectious, they survived and passed on a genetic code so that a different cell of the immune system will eliminate this pollen. A different immune response. As for these worms we are not capable of even finding them in our bodies. The only time we seem to find out is when THEY make their presence known. When they become visible, such as the African eye worm Loa Loa. When it comes into the eye you know you are infected. If this does not happen you would never know. They live in the subcutaneous layer of skin, there are no nerve endings there, we cannot feel their presence. That reminds me, I live in a homeless shelter, there are a lot of drug addicts, the addicts that take the drug crystal meth often wind up with scabs on their bodies. This is from them scratching at what is believed imaginary bugs that are on their skin. They really have bugs, only they are not on the skin, they are in the skin. The worms like the drug, it brings them from the subcutaneous layer of skin into the dermis layer of skin. This is how they collect the molecules of the drug. In the dermis layer of skin we can feel them, we have nerve endings there. If you have rhematoid arthritis, multiple sclerosis, lupus, you may have experienced a very odd tingling sensation in the arms and/or legs. This is the sensation of the hyper migratory activity of the worm through the dermis. I do not know why, I have only experienced this once and that was last summer, my first summer of taking prednisone. I also have a skin nodule on my back now from prednisone, immune suppression is not good. The skin nodule is a raised growth of epithelial cells, about the size of a dime. This is from Onchocerca Volvulus, if I did not suppress my immune system it would not have let this happen. That's important because now we can understand that our immune system is behaving differently, we have diversity in our genome, and that is simply nature, doing what it must and trying to be successful. As for rarity of nematodes, they are far more successful than you think, they infect all life, plants, aquatic, humans, I believe there was an epidemic of Loa Loa in the United States during the 20's or 30's.
SLE 2002, pulmonary sarcoidosis, deep vein thrombosis, raynaud's
When you have eliminated the impossible, all that remains, however improbable, is the truth.