I vote call your dr.'s office first. Slow taper down/off is the rule, but if disease activity is increasing significantly as evidenced by increased symptoms, you might need a BIG increase in dosage. Like right away. My dr. is great, I wish I could share him. He says I am the best judge of how I feel and how much prednisone I need. I just call the "triage' nurse and they are great about phoning in a script.
God knows, even if I don't....
CNS Lupus 2005, APS, Hashimoto's Thyroiditis
Meds: Plaquenil, Neurontin, Thyroid, Piroxicam, Aspirin, Atenolol and Norvasc, Prednisone 5mg daily and Paxil, Ambien every night.