Hi, Lyrica can take up to a week to reach it's full effects and for you to notice any difference, if any. I've been taking it since February. I had alot of low back pain, muscle spasms & cramps, and nerve pains (though I do have lumbar spine problems aside from lupus). My Rheum was the first one to prescribe it for me but he told me it would "help my muscles feel better". Well, my muscles were not aching.. he had diagnosed me years ago with Fibro also, so that's probably what he was thinking when he prescribed me the Lyrica. Well, it does absolutely nothing for my muscle cramps or spasms, nor does it help any of the deep achiness I have in my lumbar spine, hips, sacral area, and pelvic girdle. But the Lyrica did help my nerve pains somewhat, even at 50mg per day. In my opinion, I think the deep aches and some of the cramp-like feelings I have are due to my spine (I had severe spinal stenosis & had surgery; I have alot of scar tissue in there; I have spinal arthritis that is diagnosed by x-ray's, MRI's, etc...) My spine surgeon thinks my hips are now causing me alot of my pain so I don't know. I cannot get any more imaging done now as I have no insurance coverage for it. But thankfully I went back to Pain Management and among other things, they now prescribe me Lyrica at higher doses and it does help alot with my nerve pains & symptoms. I still get them but not as much.
I've also been on Plaquenil for...I don't even know now, it's at least 3 years, probably more. I've taken 400 mg per day since the get go, though I did have to take oral prednisone at the same time for 8 months to get a flare under control. Since taking Plaquenil, I've not really had much of that severe fatigue, where you just can't move and want to sleep all the time. My hair also stopped falling out and I wasn't getting any rashes up until last summer. So something is going now with my rashes, but I don't know what. I mean, Plaquenil is pretty good to control mild Lupus, but one can still get flares. I've gotten some, but they were no where near as bad as before. (well, with the exception of when I get steroid injections into my spine....when those steroids wear off, then I get hit by a freight train).