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Regular Member

Date Joined Aug 2006
Total Posts : 142
   Posted 11/15/2008 1:22 AM (GMT -6)   
Hi everyone-
I just wanted to share something with you. My doc started me on Sulfasalazine a few months ago and I have noticed a big difference with my stiffness. I used to get stiff for the first couple hours in the am and again in the evening til I went to bed. (Im sure most of u guys do too) I was taking Celebrex 200 mg/ day and my primary didnt want to increase it because of heart problems, ulcers, blah, blah, blah.... but my rhemie said it was fine. Anyhow my rhemie put me on this. I take 1 gram twice a day and I'm still a little stiff, and still have joint pain but it doesn't take me 2 hours to get going anymore unless (most days). And I used to take 4 or more doses of Tylenol every day and alternate with Ultram. Now i just take the Ultram about twice a day. And I stopped the Celebrex. The Celebrex was the only thing that helped me in the morning. So its not a miracle cure, but I definately noticed a steady decrease in the stiffness. Its an older drug but they use it for RA and Crohns so anyone having GI symptoms may benefit too. I just worried about all the Tylenol and the Celebrex because they do have some long term side effects so I was actually glad he changed it. Has anyone else taken this? Had a good response? 
Dx: UCTD,Raynaud's,iron deficientcy anemia,proteinuria
Rx: Multi-rec folic 500, Celebrex 200 mg, Plaquenil 400mg, Ultram PRN

Forum Moderator

Date Joined May 2005
Total Posts : 7720
   Posted 11/15/2008 10:13 AM (GMT -6)   
That is very interesting -- mainly because in Dr Wallace's "The Lupus Book" (the lupus 'bible', if you haven't heard about it) book, he points out that many lupus patients are allergic to sulfa medications -- I know I am!!!

I'm interested to see what others say about this.


Lynnwood, Co-Moderator: Lupus Forum
SLE(’00), Sjogren's Syndrome, Raynaud's Syndrome, Seasonal Affective Disorder, Depression, Herpes Simplex 1
Plaquenil, Prednisone(8mg), Piroxicam, Xanax(as needed), Trazodone, Boniva(monthly), Wellbutrin SR, Valtrex
Links: DIAGNOSING LUPUS (4 of 11), LUPUS INFORMATION, LUPUS RESOURCES, Donate to HealingWell, Drug Interactions

Forum Moderator

Date Joined May 2005
Total Posts : 7720
   Posted 11/15/2008 11:14 AM (GMT -6)   
BumbleBee1 posted in a new unnamed thread -- I think the post was meant to be here. Lynnwood

BumbleBee1 said...
This medicine is very rarely used in lupus because it makes lupus worse or can induce it. Dr Wallace lists it along with D-penicillamine and Minocycline. So the decision to use it when there is also RA or CD has to be well considered.

Regular Member

Date Joined Oct 2005
Total Posts : 130
   Posted 11/15/2008 11:27 AM (GMT -6)   
Thank you Lynnwood ! :) I was mighty puzzled where it had got to just now when you were dealing with it. Now you see it, now you don't


Regular Member

Date Joined Aug 2006
Total Posts : 142
   Posted 11/15/2008 2:06 PM (GMT -6)   
That is interesting! I didnt know that. Since I am in limbo and have no allergies (just latex) I guess he decided to try it.
Dx: UCTD vs autoimmune spondyloarthropathy vs psoriatic arthritis (ie Limbo x5 yrs) Raynaud's, proteinuria
Rx: Plaquenil 400mg, Ultram PRN, Sulfasalazine 2 gram

Regular Member

Date Joined May 2007
Total Posts : 482
   Posted 11/15/2008 8:48 PM (GMT -6)   
Just adding my two cents. My 28 year old son was diagnosed with psoriatic arthritis about 6 months ago and this is the medication he is on. He has noticed a lessening of his joint pain, but whenever the weather changes he still needs some type of pain medication. One thing that you should know, the sulfasalazine has made him EXTREMELY sun sensitive. I know that avoiding the sun is important for anyone with an auto-immune, but his sensitivity is very high! Apparently, the medication lists sun sensitivity as one of it's side effects. Just something you might want to be aware of!
Take care and good luck!
Take care,

Dx: Lupus, sjogren's, celiac, severe allergies.
Daily Meds: Plaquenil, Zyrtec. Prilosec, Nasacort, Prozac, Ambien CR.
Daily Supplements: Multi-vitamin, Calcium, B-100 Complex.
As Needed Meds: Epinephrine, Benadryl, Proventil, Xopenex, Tylenal, Darvocet, Prednisone.

Veteran Member

Date Joined Feb 2003
Total Posts : 5514
   Posted 11/16/2008 5:16 PM (GMT -6)   
Yup, we're supposed to stay away from any sulfa based drugs.  I'm supposed to treat them like an allergy, even though I have no idea if I'm allergic or not, LOL. 
That is interesting that your stiffness improved though Melissa, and that your son has had a good outcome with it too Fran.  Hmmmm.  Everyone's different!!
I can do anything through Jesus Christ who strengthens me. I have learned in whatever state I am in,to be content. Phillipians 4:11-13

34 years old. Diagnosed with Lupus in 2000. Fibromyalgia, anti-phospholipid syndrome(APS)(stroke),Sjogren's, Raynaud's, Libman Sach's Endocarditis, vasculitis, sacroiliitis, arthritis (neck), anxiety. Prednisone, Imuran, Coumadin, Clobazam, Amitriptyline, Didrocal, Cozaar, Zoloft, Neurontin, calcium, multi-vitamin, vitamin D, Magnesium, vitamin B6, Acidophilus

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