I had to switch from mtx to immuran, I had a bad reaction to mtx. The immuran took a couple of months to work for me, but the side affects so far (knock on wood) have not been bad at all. It seems as far as the joint pain goes it is helping quite a bit. I do take prednisone, but I'm on a very low dose, 5mg, basically a maintenance dose.
I wish you the best in getting a grip on your search for finding the right mix of meds. I know it can be hard at times. It's like mixing a cocktail at times isn't it? A little of this, a little of that, a sip to see if that works. And some nights we need a double shot of this...hehehe.
Lupus - 1997 Fibro - 2001 Sjorens - 2007 Raynauds - 2008
Plaquenil, Imuran, Prednisone, Synthroid, Topomax, Effexor, Norco, Prilsec, Xanex, Elidel, Restasis