Redspot, your story is very similar to mine. I had been on remicade for some time, and developed odd symptoms that led my rheumy to test for lupus. I did have a positive anti-dsDNA titer but the titer was low. The symptoms resolved on their own and my rheumy and GI consulted and determined that the positive antibody titer was just like those that 35% of everyone taking Remicade developed during trials and was not cause for concern. I stayed on Remicade for another 1.5 years. Finally had to stop it because I felt worse after the infusions than before. I started Humira 8 weeks after my last Remicade infusion.
I started having a fever for 1-2 days after every Humira injection. Otherwise I felt fine though did not get the over-all improvement I used to see from Remicade. Two and a half months after starting humira, I took my next scheduled injection. I awoke the next day in excruciating pain, with a fever and joint and muscle aches. GI thought this was serum sickness. When at the ER I asked about
a lupus flare but the ER docs were skeptical so did not draw any of the tests to check that.
So naturally stopped the Humira. That was December 2007. In February of 2008 I started having daily low grade fevers, extreme fatigue, and more joint pain than normal with my other diseases. My doctor thought is was likely a flare of the Ankylosing Spondylitis. Went on a short stint of prednisone which worked and I stayed good for 6 weeks. Then all the symtpoms came back plus the joints on my hands became very inflamed and swollen. I developed killer mouth sores and my hair started to fall out. More blood tests. And I got the word in June of 2008 that I had full blown Lupus.
All the information from clinical trials suggests that drug induced lupus will resolve in 4-6 weeks from the last dose. There were a few cases that took 4 months to resolve and the patient to no longer have lupus antibodies or symptoms. It has been OVER ONE YEAR for me so the doctors are not giving me much hope that this will clear. I had tests for lupus PRIOR to starting Remicade treatments because the rheumy was ruling out the possible causes of my joint pain. At that time I had a negative ANA and the other antibodies were negative.
My GI says the Remicade is the culprit. My rheumy will not say definitively that either the Remicade or Humira caused my Lupus.
If you want to talk to me more about
all this, feel free to. Dunny from the CD forum also developed lupus from Humira [or was it Remicade].
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.