The good news (or bad news, depends on how you look at it) is that the methotrexate and plaquenil take a while to start working for you. Since its only been two weeks, it makes sense that you are not feeling relief yet. When they finally start working though, for most they really do work. My doc put me on low dose prednisone before MTX until she finally decided better to do something so she put me on MTX and waited about 6 weeks before starting to get me off the pred (I'm down to 4mg today). The MTX is really helping though and I'm feeling so much better despite the pred taper although that is going slow enough.
I hope you can get some relief. Maybe your doc can rx a pred burst pac for you which may kick start you.