I have been on mtx for about two years now, maybe longer. I'm currently taking 15mg/week, which is probably my highest dose--I won't go higher. I started off on 7.5mg/week. At first, I had some issues with fatigue and nausea for a day or two after I took it, but now I don't really experience many side effects at all. And it works wonders for me. I was scared to take it for the longest time, but it appears to be the best drug for me. I also take enbrel, but could ditch the enbrel, stay with the mtx, and be fine. If your husband has some issues with it, perhaps he can try taking it at bedtime for the first few months. That's what I did, and if I experience any side effects, I end up sleeping them off.
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Methotrexate, nexium, tramadol, nasonex,Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan, zyrtec, zegerid, aciphex