Predisone/Moodswings ):

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New Member

Date Joined May 2009
Total Posts : 1
   Posted 5/24/2009 7:58 PM (GMT -6)   
Helloo, I'm Dee :)
I'm currently 19 but I was 13 when I got diagnosed with Renal Vasculitis & 16 when I was diagnosed with SLE. I was on Prednisone & I also got Chemo for 8 months. I've been in remission since i was 17 ( 2years) & been doing good with no pills or nothing. Recently I was hospitalized for a really bad lupus flareup. Not only did it attack my kidneys but it decided it was going to go for my liver. I am losing my hair pretty bad, my whole body aches I have trouble working & basically getting out of bed. I went to the doctors last wednesday & she put me back on Hydoxychloroquine (plaqunil) & 30mg of Predisone. I was completely devisated about having to take the predisone. Ever since I've been on it I've been having the moodswings pretty bad. I'm either crying my eyes out or wanting to kill someone. I just feel so alone lately & I basically feel like nobody cares. Anywhoo, My boyfriend.. my poor boyfriend I've been taking it all out on him & he's getting ready to crack I know he is. He's been trying really hard to stay calm & reasearh my lupus but I know hes at a breaking point. I was just wondering if anyone has any advice on what to do about these moodswings? If I cannot find a way to work around them I'm going to have to take my self off of my predisone cry

Veteran Member

Date Joined May 2005
Total Posts : 7720
   Posted 5/24/2009 8:28 PM (GMT -6)   
Please don't take yourself off Prednisone without your doctor working with you - it can be very dangerous (like stopping your heart dangerous).

Usually it takes 2-3 weeks for your body & hormones to adjust to prednisone and mood swings to level out. If you are taking 30 mg each day, its different than it you are on say 30 this week, 20 next week, etc.

I can help avoid mood swings by: (1) getting regular rest at regular times -- ie always up & to bed about the same time, a nap about the same time each day, whatever and (2) have regular meals at regular intervals. IE meals with protein and carbs, not just one or the other - no more than 4 hours between meals. (3) taking my meds at the same time everyday (4) remembering its a chemical mood swing and that I'm not losing my mind is a BIG help!

Please consult with your doctor about the mood swings as soon as you get a chance. They can prescribe different amounts and different schedules that will help -- and some people who are on it longer term need another med to help with the mood swings.

Hope you feel better soonest,

Lynnwood, Co-Moderator: Lupus Forum
SLE(’00), Sjogren's Syndrome, Raynaud's Syndrome, Seasonal Affective Disorder, Depression, Herpes Simplex 1
Plaquenil, Prednisone(15 5mg), Piroxicam, Xanax, Trazodone, Boniva, Wellbutrin, Valtrex, Vicodin, Prilosec
Links: Diagnosing Lupus (4 of 11), Info, Lupus Resources, Help HealingWell, Drug Interactions

Life is far too important to be taken seriously. –Oscar Wilde, 1882

Veteran Member

Date Joined Jan 2005
Total Posts : 8616
   Posted 5/24/2009 9:26 PM (GMT -6)   
Welcome to the forum Dee!!

Lynnwood gave you some great advice. I agree with NOT stopping the prednisone w/o doctor's input. Prednisone needs to be tapered very slowly (reduced gradually).

I hope things level out really soon for you. Yuppers! We have our own personal roller coaster ride!!!

Sounds like your bf is special. I have a lot of respect for a young man who will do research and try to help figure things out.

Glad you found us!


In His Grip

AlwaysRosie           "We can't control the waves, but we can learn how to surf!!"

Psalms 139

Co-Moderator - Lupus Forum

UCTD, Inflammatory Arthritis, Diverticulosis, (recent dx - Sjogrens, Crohn’s 4/08)

Clickable Links:  Lupus Resources    Lupous.Org   Lupus Criteria (4 of 11)   Lupus Chapter Locator

Regular Member

Date Joined May 2007
Total Posts : 482
   Posted 5/24/2009 9:33 PM (GMT -6)   
Hi Dee,

Lynn and Rosie are 100% correct - please do not stop your pred - it is very dangerous to do so. I'm guessing that you haven't fully adjusted to the meds, yet. Your doctor would definitely want to know what you are going through.
Sounds like you have a great boyfriend - that will help you, a lot!

Hope you are feeling better, soon.
Take care,

Dx: Lupus, sjogren's, celiac, severe allergies.
Daily Meds: Plaquenil, Zyrtec. Aciphex, Nasacort, Prozac, Ambien CR.
Daily Supplements: Calcium, B-100 Complex.
As Needed Meds: Epinephrine, Benadryl, Proventil, Xopenex, Tylenal, Darvocet, Prednisone.

Veteran Member

Date Joined Jun 2008
Total Posts : 1470
   Posted 5/25/2009 9:44 AM (GMT -6)   
Hey There! Welcome to the forum. I have been where you are with the mood swings. One moment I would be laughing so hard I could harldy breath and then the next moment in tears or on the verge of jumping down someone's throat. As Lynn, Rosie, and Fran have said, DO NOT STOP taking prednisone without consult of your doctor. I was pretty new to the drug a few months ago and didnt realize what all it did. I had 35 pds gained in one month, moon face, stretch marks, mood swings, and basically feeling crappy to name a few! I decided to cut back on my prednisone. Not a good idea! I would not advice anyone to do that. Also, if you are having kidney and liver problems it is a huge part on what is keeping them under control! I am guessing you are either on cellcept or cytoxan! My doctors have told me that prednisone has to be used with these 2 drugs, in the beginning because of how quickly it works. Gradually they have brought my prednisone down. I am currently on 15 mg and am feeling better than ever. My joint pain isnt disabeling, the muscle weekness, mood changes and all the whacky side effects from the drug are slowing dying down (except the stretch marks) Stick in with it, it is so important to follow the doctors directions. If you ever wanna talk to someone close to your age about lupus or want to vent, feel free to email me! I am 21 and was diagnosed in NOV 07. Once again, welcome to HW and I pray things will look better for you!!!



21 years old...Systemic Lupus , lupus nephritis , raynoids , Carpal Tunnel

Ultram, Prednisone, Cell-Cept, Lisinopril,  Ambien, Flexeril, Darvocet, Ferrious Sulfade, Calcium, Vitamin B12, Aspirin 81 mg, Vitamin C

Regular Member

Date Joined Jun 2008
Total Posts : 363
   Posted 5/28/2009 7:21 PM (GMT -6)   
Just knowing that the pred is causing these mood swings will help. Remind yourself of that before you say anything. Find a good friend, counselor or clergy if you're religious to talk to about everthing that is on your mind. Getting it off your chest in a planned healthy atmosphere is so much better then just blowing up. I must admit, though that the blow ups do make me feel better. So I meet with my priest regularly, just to keep my head on straight. My husband is very thankful. Keep strong and God Bless.


PCP pretty convinced- Lupus , Taking plaquenil,Propranolol,  Flexeril,Claritin, Zantac,Ambien,vitamin B-12, multi- vitamin, Lortab.  Prednisone 15mg daily added 03/09.   Mom of 2 boys 1 and 6.  Symptoms: Fatigue, joint pain, heat/sun sensitivity, mouth and nose sores, malar rash, migranes, awful hives, positive ANA, and RF.



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