I can't take most things, cyp3A4 inhibitors are the primary problems. I have problems with some anticholinergenics and GABA inhibiting drugs (neurontin, lyrica, gabatril) too. My problems often only occur after a month or so of use, but I get bad sideeffects during the entire time. The rash usually starts after a month or so. Some meds are so bad I can't tolerate for more than a few days. My doc explained that in my case my liver is like a sieve, a filter, and mine is so full of fat that meds with large or complex molecules cannot fit through the decreased holes in the filter and the drugs back up in my system. My body views it as toxic, then the fun starts.
I do better on choliinergenic and pro GABA drugs. Apparently I need more choline and GABA, not less.
I found amazingly good info on a meds to avoid list for porphyria. I don't know if there is some component of porphyria to some autoimmune diseases, but it read like a list of my allergies. It is a good resource for over the counter and other substances, to check to see if they increase sun sensitivity, which we all seem to have.
My mom has ulcerative colitis and is allergic to nearly everything, including aloe and lanolin. Her allergies seemed to accumulate with age.
Allergc reactions are caused by histamines, origin in the liver. Sparing your liver from unnecessary damage can help with reducing the chances of developing new allergies for me. I don't know if this helps but I hope you can find a balance. Just make sure you check and take care of your liver yourself, too. Many docs feel liver damage is an appropriate sacrifice for quality of life, but with a little more effort and research, they often can find a better compromise.
Ills--Sjogrens-Lupus cond., AI polygland. dysfunction 2, hyper/hypopigment, scoliosis,kyphosis,stenosis, deg.,O.A.,spine surgeries, salivary/lymphectomies, NASH, COPD, RLS, UT/GI bleeds, hystero, brain/nerve damage,TB
Meds--INH,Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, HRT and Lidocaine patchs, Voltaren gel, Klonopin, Vicodin, Restasis, Albuterol, steroids