Plaquenil (anti malarials) are they immuno suppresants?

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Angel MJ
Regular Member

Date Joined May 2009
Total Posts : 36
   Posted 6/23/2009 3:42 PM (GMT -7)   
hi all ... just wanted to start a thread to debunk something i've seen on many lupus boards ... please understand that i am *just* a patient and get my information from doctors and not off random websites

are anti malarials immuno suppresants?

i've copied a very insightful response someone made on another board

In his hardcover, Dr. Daniel Wallace devotes a whole section to Plaquenil. He actually says it's NOT an immune suppressant, unlike the other 2 categoreis of DMARD's (= steroids & flat-out immunosuppressants). He describes how it alters the acid/base ratio in our cells, which somehow discourages production of unwanted autoantibodies. Something like that, anyway...

please feel free to add your comments

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Date Joined May 2005
Total Posts : 7653
   Posted 6/23/2009 4:42 PM (GMT -7)   
That's correct, it is NOT an immumosuppressant, but it is known to inhibit the progression and flares of lupus.

It is well documented in Dr Wallaces's book, which is well-known as "THE lupus bible" across the world. That is why it is almost always prescribed at the first visit if lupus is suspected, even before tests are run.

Lynnwood, Lupus & Sjogren's Moderator
Life is far too important to be taken seriously. - Oscar Wilde, 1882

Regular Member

Date Joined Aug 2005
Total Posts : 215
   Posted 6/24/2009 9:38 AM (GMT -7)   
It was originally used as an antimalarial drug. It has an antiflamitory agent which originally was used to decrease fever in those with malaria. Im not sure how they figured it would work with lupus or RA, trial and error maybe. Thank God for it though
sle 92, fibromyalgia 95, t4 fracture 06, hyperthyroid with nodules 05, pernisious anemia 04,
? lupus vasculitis lungs, osteoporosis, c3-4 t1 herniated disks 00, gerd, depression
APLS, hyperthyroid, thyroiditis, complex thyroid nodules, asthma, stiff heart with 4 valve regurg., hemolytic anemia, supraventricular tachycardia
meds:prednisone, plaquinil, imuran, hydrocodone, flexeril, ibprofen, asa, fosamax, prilosec,

Veteran Member

Date Joined Dec 2007
Total Posts : 2113
   Posted 6/24/2009 7:18 PM (GMT -7)   
I agree, thank God for it. I have RA and plaq gave me my life back.
It is not an immune suppressent but it does suppress the immune system and leave people somewhat more vulnerable to infections.
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