Naprosyn for lupus?

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Regular Member

Date Joined Oct 2008
Total Posts : 261
   Posted 7/2/2009 5:34 PM (GMT -6)   
Just wondering if anyone else has been treated with naprosyn for their lupus. I am undiagnosed but was put on 375mg of naprosyn after having 3 pos anas and cpks and told its AI but not specific enough for lupus yet and was wondering how it worked for you all. Honestly I have not seen much change. My pain is lessened but I still have all my symptoms and am actually flaring again now since 2 nights ago. I have been on the naprosyn for a week now. It seems like it is just covering up pain and not getting rid of what is really there. My dr wants to try to increase the dose before trying plaquenil but I am just frustrated because I am not feeling better. Anyone else in the same boat?
*Wifey & Mommy*

Regular Member

Date Joined Aug 2007
Total Posts : 206
   Posted 7/3/2009 9:23 AM (GMT -6)   
Its common for a dr. to put you on an anti-infammatory before going to a more aggressive type of treatment. With Lupus, drs. can treat the symptoms. You must have pain and inflammation? I know when I was first on this road my dr. had me taking up to 8 ibuprofen a day. His theory is (especially if it doesn't turn out to be lupus) if it was possibly arthritis coming on sometimes if you hit it hard at first it may stop it in the future. If you hurt less that would be the goal with taking naprosyn. Unfortunately like most of us here it sounds like you are in a waiting game to figure out just what is going on. You've probably heard all of this before too, but even if your dr. does start you on plaquenil it does take some time for it to work. I found I was allergic to it so now I'm on methotrexate, but I still take 2 anti-inflammatorys a day, and more recently I had to trade those for a prednisone taper. Hang in there, its hard to be patient and try to keep your sanity, but stress can bring some of the symptoms on so make sure you rest and take care of yourself. Good luck!
 "Challenges make you discover things about yourself you never really knew."
 SLE and Class II Lupus Nephritis

Veteran Member

Date Joined Jan 2004
Total Posts : 4151
   Posted 7/6/2009 10:49 AM (GMT -6)   
I was first put on Naproxen and then eventually Plaquenil and Naproxen. It did help some but decided not to work after a while. Doc then put me on Lodine XL to go along with the Plaquenil which I'm still on today. That worked for a while but still had quite a bit break through pain so I'm now on that plus Methotrexate. I'm doing well now but I'm really glad that the doc took me in steps. It would be very irresponsible for docs to pull out the big guns in the beginning if you are not having life threatening issues. I know its frustrating, there are lots of NSAIDs... I mean LOTS. Some work for certain individuals while others not so much. Some docs might even try different kinds to find one you respond to.

These AI diseases are so tricky and they are very hard to diagnose. Even if you do have antibodies... a lot of the diseases share certain antibodies so they are not always very specific except for a couple of them. It sounds like your doc is trying to get you on a treatment plan and yes it does take some time to see if the meds are working. Like the saying goes, 'hurry up and wait' Docs need to weigh out the benefit and risks of the long term effects of the medications.
Dx: IBS 1989, Diverticulosis 2004, Idiopathic Acute Colitis 2006, UCTD 2007, Localized Scleroderma 2009, Raynauds 2009
Meds: Plaquenil 400mg/day, Pred 2.5 mg/day (tapering), Methotrexate 10mg/week, Hydrocodone PRN, Flexeril PRN, Fiorinal PRN, Baby aspirin, Prenatal Multi, Vit E, B12, Fish Oil, Biotin, Calcium, Folic Acid

Regular Member

Date Joined Oct 2008
Total Posts : 261
   Posted 7/8/2009 12:14 PM (GMT -6)   
Thanks. I was just wondering how long do they wait between meds to see if they work? I have been on naprosyn 375mg twice a day for 2 weeks helps with some stiffness and i haven't had any migraines yet this month but other than that the burning leg pain is awful and worse at night so im gonna have to get a full nerve study and emg and see a neuro at lol
*Wifey & Mommy*

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