Has anyone tried Lyrica?

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Veteran Member

Date Joined Mar 2006
Total Posts : 2608
   Posted 7/5/2009 11:19 AM (GMT -6)   
I believe that much of my pain is due to fibromyalgia. My doctor won't prescribe anything stronger than Ultram (tramadol) and it doesn't cut it. I'm having trouble dealing with the pain.

From what I've read, it seems that the side effects of Lyrica can be unpleasant, such as mood changes and weight gain, neither of which I need.

Does anyone here have any experience with this drug?
SLE, fibro, renauds, restless leg, hiatal hernia, double vision, migraines, costocondritis.

prednisone, plaquenil, leflunomide, neurontin, synthroid, triamterene, actonel, niaspan, tri-est, cymbalta, tricor, acifex

Veteran Member

Date Joined Jun 2008
Total Posts : 1470
   Posted 7/5/2009 12:15 PM (GMT -6)   
I don't know much about lyrica but I have also been in a crap load of pain and my doctor prescribed Darvocet and Ultram together. Let me tell u, it has worked better for me than the stronger drugs. I will take 1 ultram (50mg) and 1 darvocet and if the pain hasnt let up in an hour, will take another ultram! Maybe you could give that a try?



21 years old...Systemic Lupus , lupus nephritis , raynoids , Carpal Tunnel

Ultram, Prednisone, Cell-Cept, Lisinopril,  Ambien, Flexeril, Darvocet, Ferrious Sulfade, Calcium, Vitamin B12, Aspirin 81 mg, Vitamin C

The Old Normal is no more so I and we have to find a New Normal...


Veteran Member

Date Joined Feb 2003
Total Posts : 5514
   Posted 7/5/2009 1:32 PM (GMT -6)   
My rheumy doesn't think that Lyrica is worth all the praise it gets.  She's not convinced, so she won't prescribe it for me.  HOwever, Neurontin (Gabapentin) is amazing.  For me, it has been an excellent pain med. 
I can do anything through Jesus Christ who strengthens me. I have learned in whatever state I am in to be content.Phillipians4:11-13
35 years old. Diagnosed with Lupus in 2000. Fibromyalgia, Anti-phospholipid syndrome(APS)(stroke, 2002), Sjogren's, Raynaud's, Libman Sach's Endocarditis, vasculitis, sacroiliitis, arthritis (neck), anxiety, Chinook migraines. Prednisone, Imuran, Coumadin, Clobazam, Amitriptyline, Didrocal, Cozaar, Zoloft, Neurontin, calcium, multi-vitamin, vitamin D, Magnesium, vitamin B6, Acidophilus
 Co-Moderator for the Lupus and Fibromyalgia forums

Veteran Member

Date Joined Jan 2007
Total Posts : 607
   Posted 7/5/2009 1:46 PM (GMT -6)   
I am taking Lyrica for nerve pain, and for me, it's better than Gabapentin. I have not experienced any sign effect except the drowsiness. I have been taken it for more than a year now.
DX SLE 1988; APS (Antiphospholipid Syndrome) Pred 10mg, Verapmil 40 mg bd (for migraine headaches), Cellcept 1000 mg;Omerprazole 40 mg; Warfarin; Calcium + Vitamin D 1200mg, Folic Acid 5 mg; Iron; Simvastin; pregablin 75 mg

Regular Member

Date Joined Feb 2009
Total Posts : 108
   Posted 7/5/2009 4:00 PM (GMT -6)   
Love my Lyrica! Tried Gabapentin, but it didn't touch the nerve pain I have. I have not had alot of side effects other than when they first started me on it, the dosage was too high and I had massive tremors until they lowered the dose. But have not had any weight gain (thank goodness!) or extra mood swings (again, thank goodness) from it.

I think it's different for everyone.

There are only two ways to live your life.
One is as though nothing is a miracle.
The other is as though everything is a miracle.
-Albert Einstein

Dx: SLE, Sjogren's, Reynaud's, Peripheral Neuropathy

Regular Member

Date Joined Oct 2007
Total Posts : 185
   Posted 7/5/2009 6:03 PM (GMT -6)   
I know a lady from another board and she has been on it and gained a huge amount of weight...

Regular Member

Date Joined Aug 2005
Total Posts : 215
   Posted 7/5/2009 9:24 PM (GMT -6)   
Lyrica works wonderful on my nerve pain. The only side effect I have is it makes me feel like Im drunk so I only take it at 6pm and by 10 Im able to sleep good. I also would never ever think of driving while taking it.

Lupus (SLE), fibromyalgia, T4/T5 & L fractures, hyperthyroid, pernisious anemia, Interstitial lung disease, vasculitis, neuritis, osteoporosis, gerd, APS, thyroiditis, complex thyroid nodules, asthma,  4 valve regurg., hemolytic anemia,

Veteran Member

Date Joined Dec 2005
Total Posts : 1950
   Posted 7/5/2009 9:29 PM (GMT -6)   
People either seem to love it or hate it. I cannot take it, it is very hard on the liver and I'm allergic. It also increases my pain. Ifound that during my worst times, I hadto take six ultram a day each and every day and keep it in my system to have it work. Pred works for my pain. I did take a very low dose of imipramine for a long time until I developed nerve problems. It also works for fibro. I take klonopin at night, and the klonopin helps the ultram work better.

You might try a pain center, if you aren't already there. They may have more options. There are some new topical pain meds and patches and topical muscle relaxers as well that have a low abuse potential, and are more easily tolerated, if you have trouble tolerating the lyrica. I hate seeing people have to make a choice between damaging their liver and kidneys and suffering in pain. It shouldn't be that way.

I'm not the greatest case for these new antiseizure, antipsychotic drugs being used for pain. They simply made me not care and then made me sick. There are meds that increase and decrease the effects of GABA and their are anticholinergic and cholinergenic drugs, and your pain can be made worse or better so its important they figure out for sure that you don't have other problems.

Vitamin B6 helped/helps me alot, and some say B12 or other B vitamins. I'm talking about totally alleviating severe numbness in my arms. My liver just doesn't metabolize vitamins all that well due to all the meds and my illness, my kidneys aren't so hot either.

Also, bioidentical hormone replacement really helped my fibro. An MD/ob/gyn who prescribes bioidentical hormones can test your vitamins and hormones and proper supplementation really helps as well as some meds for some people. I really underestimated how great a positive change they make. It is definitely worth a try regardless, esp. if you've had a hystero or other problems. Lyrica can be hard to get off of and there have been lawsuits.

It never hurts to get the vitamin and hormone thing checked, they do seem to matter alot in my pain and others have said the same.
Love, Marji
Ills--Sjogrens-Lupus cond., AI polygland. dysfunction 2, hyper/hypopigment, scoliosis,kyphosis,stenosis, deg.,O.A.,spine surgeries, salivary/lymphectomies, NASH, COPD, RLS, UT/GI bleeds, hystero, brain/nerve damage,TB
Meds--INH,Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, HRT and Lidocaine patchs, Voltaren gel, Klonopin, Vicodin, Restasis, Albuterol, steroids

Veteran Member

Date Joined Jan 2004
Total Posts : 4151
   Posted 7/6/2009 11:10 AM (GMT -6)   
My experience on it is the same as mypearl, which is why I don't take it anymore. I was taking it for peripheral neuropathy. Yeah, it worked on the pain but I could not function. It felt like it made my fatigue 5 times worse and to me just wasn't worth it, especially when I have a full time job. Maybe if I had given it time to build up in my system, the side effects wouldn't have been as bad but I just didn't have to time to do it with work.
Dx: IBS 1989, Diverticulosis 2004, Idiopathic Acute Colitis 2006, UCTD 2007, Localized Scleroderma 2009, Raynauds 2009
Meds: Plaquenil 400mg/day, Pred 2.5 mg/day (tapering), Methotrexate 10mg/week, Hydrocodone PRN, Flexeril PRN, Fiorinal PRN, Baby aspirin, Prenatal Multi, Vit E, B12, Fish Oil, Biotin, Calcium, Folic Acid

Veteran Member

Date Joined Mar 2006
Total Posts : 2608
   Posted 7/7/2009 9:15 AM (GMT -6)   
I really appreciate all of your feedback! I take 1200 mg of gabapentin at bedtime already. I wonder if I should take smaller amounts during the day. It does make me drowsy, but I can't sleep without it.

I don't think Lyrica is for me, esp. if I had to stop taking neurontin. Can they be taken together.

Since I've been keeping my granddaughters I've gained 10 pounds. Cooking 3 meals a day and eating with them. So anything that might cause weight gain is not in my future. Weleetka, I've heard that too.

Amy, I wish my doc would prescribe something like Darvocet to take with my Ultram. By the way, I take 1 extended release Ultram a day so it stays in my system. But it's just not enough.

Ginny, I'm going to talk to my rheumy about it, but since Neurontin is working well for me at night, plus I've been taking it for years, I doubt I'll change.

But then Omega, Mypearl and Anne love it.

Marji, I was taking Tri-Est, which is a bioidentical estrogen and for no reason at all, I stopped taking it months ago. I've thought about starting it again, but what stops me is the fear that it will cause weight gain. I have an appointment with my PCP in a couple of weeks and plan to talk to her about options for my pain and depression. A pain center might be a good option if she'd refer me.

Dbab, I understand what you mean about fatigue. I have more than I need already!

I'll let you guys know what my PCP says about all of this. And again, thanks for all the feedback! You are all wonderful.

SLE, fibro, renauds, restless leg, hiatal hernia, double vision, migraines, costocondritis.

prednisone, plaquenil, leflunomide, neurontin, synthroid, triamterene, actonel, niaspan, tri-est, cymbalta, tricor, acifex

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