Hey there! I just signed on and was going to update about
my own methotrexate experience. I am also on 10mg and have had 3 doses so far. I am right there with you... I have had some mixed feelings for sure. It took me a year to make the decision to take this medication. I can't take prednisone with out very severe anxiety. I have severe stomach problems from my illness (inflammation) to begin with. So I have a bleeding problem with NSAIS meds. Plaqunil is something I can't function without. However, I am not yet able to work or participate in many daily activities anything close to "normal" and still experience high levels of pain. So I have started methotrexate. I knew I may have side effects and they may be similar to some of my symptoms. I take my dose at night! I would recommend that for sure. I am surprised you made it to dinnertime..
The first time I didn't notice how quickly I was tired. But the next to times it put me right out. And I agree with you- the next morning it was like "instant flu". However, I have noticed a few things already. My pain levels related to my illness have begun to decrease. A few days after the treatment I have some situational depression- I feel like "why the heck am I doing this to myself"....I am reminded of when I was first pregnant..but worse. I just can feel the whole toxic effect. However, the truth is i have heard your body gets used to it after a while and the side effects lessen. I plan to give it time because the alternative is to continue to not get any improvement from the illness. This for me, has been more depressing. So, as you see, I have mixed feelings....
Today is Wednesday (well tomorrow will be) and I started to feel better Sunday this time. I am having some lupus symptoms but the pain is much less. All week I have no appetite and I have started to drink Ensure...almost daily and most days I can eat about
one meal. I also can't exercise yet. I was getting some walking done before the treatment. I am keeping up the hope though. I would suggest you give it some time. I would also suggest you talk to your doctor about
letting your body adjust to your current dose and getting your liver tested first before your dose is increased. I am going for my first liver enzyme test next week. I think 10mg is the Ave. first dose for lupus or RA. I did go for a second opinion to another Rhuemy and she stated mine was on the right track and typically if someone tolerates the medication, the dose will be raised.
I hope this was of some help. I certainly feel ya!!!! Let's keep in touch since we both started at a very similar time.
CTDU/Probable SLE- Peripheral Neuropathy, Partial Complex Seizures, Severe and chronic joint pain/fatigue, Sun sensitivity, butterfly rash, vitamin D deficiency, skin rash in sun, Skin rashes, mouth, lip, nose sores, Hair loss, head sores, some muscle pain, Muscle cramps, Vascular: Raynoids syndrome, Hx of Pericarditis x 4, Severe Dry mouth, persistent, Thyroid Disease, hx of moderate asthma, lung inflammation at onset of illness, hx elevated RF, recent protein serum elevated. No positive ANA yet
Methotrexate, 2.5 mg (4tabs 1x a week) Folic Acid (1mg daily), Plaqunil 600mg day, Topomax 200mg day (neurapathy), Ultram 100mg (prn) pain, flexaral, pm for feet cramps, Synthroid .50 micro, estrogen patch, lexapro 5mg, (mild anxiety),
~nothing is impossible~