methotrexate kicking my butt

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Regular Member

Date Joined Jan 2008
Total Posts : 102
   Posted 7/26/2009 5:21 PM (GMT -6)   
I havent posted in awhile just started taking methotrexateon Friday. Felt ok till about 8pm I took it with my lunch. I felt so wiped yest like I was hung over or the flu without the vomiting. Is this normal she started me on 10mg for two weeks then I will up in two weeks. Im a little scared because of how I felt yest. I could'nt even get out of my own way. Im also suppose to be going away the day I up it to my grandparents camp closest hosp two hours away. I feel bad not going, but I dont want to be up there sick. Please help me Today I felt ok when I first got up but feeling worse as day goes on. not like yest though thank god... I need feed back or suggestions.
SLE, APS, Food Allergies, Gerd, Migrains
Prilosec, zoloft, Plaquenil, asprin, predisone, cellcept..

Veteran Member

Date Joined Jul 2009
Total Posts : 4796
   Posted 7/26/2009 5:44 PM (GMT -6)   
Hi, JessieRose,

Sorry to hear the Methotrexate is not agreeing with you. I am taking a lower dosage,
7.5 mg and have been on that dose since April. My Rheumy told me to take it with my
evening meal. Haven't had any flu-like symptoms, although I just found out my liver
enzymes are elevated. I do know that nausea is a main symptom for some people
when they are first starting methotrexate.

You might want to call your Doctor's office and discuss your symptoms to give you peace
of mind before you go on your trip. Hope everything works out for you.


Regular Member

Date Joined Jan 2008
Total Posts : 102
   Posted 7/26/2009 5:59 PM (GMT -6)   
Thank you Robin, I prob will call tom morning.
SLE, APS, Celiac,
 Zoloft, Plaquenil, Asprin, Predisone, Methotrexate, Folic acid

Veteran Member

Date Joined Jul 2007
Total Posts : 1048
   Posted 7/26/2009 8:44 PM (GMT -6)   
Bless your heart! I hope you start feeling better soon! Let us know what the doc says. Judy

Veteran Member

Date Joined Sep 2005
Total Posts : 2573
   Posted 7/27/2009 2:42 AM (GMT -6)   
When I have a medicine that upsets my stomach I take it before bed so I can sleep through the nausea. I know nothing about methotrexate except that I have heard it takes some getting used to.
Dx:fibromyalgia 2002, systematic lupus 2005- definate CNS involvement dxed late 2005, psoriasis 2006, rheumatoid arthritis 2006, PTSD 2007, multiple allergies 2005, migraine, compression fractures T11 & T12, Sj√∂gren's, damaged periphrial nerves 2007, exema
Tx: plaquenil, Enbrel, Tramadol, Singulair, Skelaxin, Baby Asprin, Imuran, Prilosec, lasix, Evoxac, Celebrex, Darvocet when things get too bad, prednisone again, various vitamin/mineral supplements, cozar

Veteran Member

Date Joined Sep 2005
Total Posts : 1744
   Posted 7/27/2009 6:57 AM (GMT -6)   
Sorry to hear that mtx is making you sick.  I take 15 mg/week, but I started off on 7.5mg and worked my way up.  I also took it right before bed so that if I had stomach side effects (which are common), I would theoretically sleep through it.  Plus, mtx sometimes makes me tired for a day or two after I take the weekly dose.  I've been taking it for almost a year now, though, and my body has adjusted to it.  The side effects do go away after a few weeks, at least for some people.  If it's too bothersome for you, I understand that mtx is also available as an injection, so you wouldn't experience any stomach side effects at all.
Hope you feel better soon,
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Lupus
Current Meds: Enbrel, Methotrexate, nexium, tramadol, nasonex, Nifedipine, Folic Acid, Tylenol PM

Veteran Member

Date Joined Oct 2004
Total Posts : 2244
   Posted 7/27/2009 9:06 PM (GMT -6)   
Hi Jessierose,

I always take my dose of MTX on the weekends, at night after dinner, it minimizes the nausea. Are you also taking folic acid? I know there is a med your rheumy can prescribe for nausea but I don't know the name. If it does not improve in the next week or so you should call your rheumy and let them know how you are feeling.

Take care
Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Lupus, Sjogrens, Raynaud's, Hashimoto's and Celiac Disease
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Folgard OS (B12), Vitamin D-50,000 IU, Tramadol (as needed) and magic mouthwash (for mouth sores)

Regular Member

Date Joined Jan 2008
Total Posts : 102
   Posted 7/28/2009 6:43 AM (GMT -6)   
Well this morning I feel better like myself just a little tired. I even went to the gym. cool   Does anyone know do you have to take it exactly the same day every week. I took it on friday last week and I was thinking I would take it thursday night. I dont have to work on friday, and was thinking I could stay in bed all day then still have some weekend time. Also I know it says not drink, but can I have one glass of wine if I wanted?. Thank you for all the kind words. It nice to have people to talk to that understand whats going on.
SLE, APS, Celiac,
 Zoloft, Plaquenil, Asprin, Predisone, Methotrexate, Folic acid

Veteran Member

Date Joined Mar 2006
Total Posts : 2608
   Posted 7/28/2009 8:49 AM (GMT -6)   

I had a similar experience when I took methotrexate. I took it on Saturdays and until about Thursday of the following week I felt awful. Nausea, and debilitating fatigue. I learned to make appointments only on Thursdays and Fridays because those were the days that I felt halfway normal.

Please talk to your doctor about the side effects you're experiencing. He may elect to change you medication or not increase the dose at this time.

Let us know what he tells you.

SLE, fibro, renauds, restless leg, hiatal hernia, double vision, migraines, costocondritis.

prednisone, plaquenil, leflunomide, neurontin, synthroid, triamterene, actonel, niaspan, tri-est, cymbalta, tricor, acifex

New Member

Date Joined May 2009
Total Posts : 17
   Posted 7/29/2009 12:17 AM (GMT -6)   
Hey there! I just signed on and was going to update about my own methotrexate experience. I am also on 10mg and have had 3 doses so far. I am right there with you... I have had some mixed feelings for sure. It took me a year to make the decision to take this medication. I can't take prednisone with out very severe anxiety. I have severe stomach problems from my illness (inflammation) to begin with. So I have a bleeding problem with NSAIS meds. Plaqunil is something I can't function without. However, I am not yet able to work or participate in many daily activities anything close to "normal" and still experience high levels of pain. So I have started methotrexate. I knew I may have side effects and they may be similar to some of my symptoms. I take my dose at night! I would recommend that for sure. I am surprised you made it to dinnertime.. smhair The first time I didn't notice how quickly I was tired. But the next to times it put me right out. And I agree with you- the next morning it was like "instant flu". However, I have noticed a few things already. My pain levels related to my illness have begun to decrease. A few days after the treatment I have some situational depression- I feel like "why the heck am I doing this to myself"....I am reminded of when I was first pregnant..but worse. I just can feel the whole toxic effect. However, the truth is i have heard your body gets used to it after a while and the side effects lessen. I plan to give it time because the alternative is to continue to not get any improvement from the illness. This for me, has been more depressing. So, as you see, I have mixed feelings.... cry confused eyes skull Today is Wednesday (well tomorrow will be) and I started to feel better Sunday this time. I am having some lupus symptoms but the pain is much less. All week I have no appetite and I have started to drink Ensure...almost daily and most days I can eat about one meal. I also can't exercise yet. I was getting some walking done before the treatment. I am keeping up the hope though. I would suggest you give it some time. I would also suggest you talk to your doctor about letting your body adjust to your current dose and getting your liver tested first before your dose is increased. I am going for my first liver enzyme test next week. I think 10mg is the Ave. first dose for lupus or RA. I did go for a second opinion to another Rhuemy and she stated mine was on the right track and typically if someone tolerates the medication, the dose will be raised.

I hope this was of some help. I certainly feel ya!!!! Let's keep in touch since we both started at a very similar time.
CTDU/Probable SLE- Peripheral Neuropathy, Partial Complex Seizures, Severe and chronic joint pain/fatigue, Sun sensitivity, butterfly rash, vitamin D deficiency, skin rash in sun, Skin rashes, mouth, lip, nose sores, Hair loss, head sores, some muscle pain, Muscle cramps, Vascular: Raynoids syndrome, Hx of Pericarditis x 4, Severe Dry mouth, persistent, Thyroid Disease, hx of moderate asthma, lung inflammation at onset of illness, hx elevated RF, recent protein serum elevated. No positive ANA yet

Methotrexate, 2.5 mg (4tabs 1x a week) Folic Acid (1mg daily), Plaqunil 600mg day, Topomax 200mg day (neurapathy), Ultram 100mg (prn) pain, flexaral, pm for feet cramps, Synthroid .50 micro, estrogen patch, lexapro 5mg, (mild anxiety),

~nothing is impossible~

Barbara Lee
Veteran Member

Date Joined Sep 2003
Total Posts : 2889
   Posted 7/29/2009 12:21 PM (GMT -6)   
Hi JessieRose:
I've been on methotrexate for about 1 1/2 yrs.  In the beginning I had the flu like symptoms and a bit of nausea.  I take 25 mg once a week, I take Folic Acid with it to help with any mouth sores I may get.  I've grown accustomed to the medication.  I take mine on Monday mornings and Tuesday I'm a bit more tired but the flu like symptoms are gone.  Give it a little bit of time and see if you improve.  If you don't I'd call my Rheumy and let him know that you're not doing well on it.  There is an injectable form for those who have a lot of nausea.  If your nausea is mild but you'd like something for it I'd recommend Zofran it doesn't have the sedating effect that phenegran has.  Hope things being to improve for you.  Let us know how it goes.
Take care,
dx fibro, SLE, glaucoma, cateracts, bells palsy, depression, migraine headaches, gastreopaersis, chronic anemia, RA,MDS (Blood Cancer). Tons of meds.

Regular Member

Date Joined Jan 2008
Total Posts : 102
   Posted 7/30/2009 6:00 PM (GMT -6)   
Christine, That is exactly how I felt with feeling depressed on monday. Just took it 1/2 hour ago just sitting on couch with my pillow, remote water,and of course the computer. Thank you for the imput it was really helpful..
SLE, APS, Celiac,
 Zoloft, Plaquenil, Asprin, Predisone, Methotrexate, Folic acid

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