Plaquenil scare..

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Veteran Member

Date Joined Feb 2003
Total Posts : 5514
   Posted 8/30/2009 8:10 PM (GMT -6)   
Hey all, sorry I haven't been around much latelyl.  I'll do better when my busy wedding season is over at the end of September.
I had a scare this morning.  I woke up feeling nauseated, diarrhea, itchy skin and a low-grade fever, hot and cold sweats.  those are the symptoms of a possible severe allergy to Plaquenil.  Some of you know my near- death med allergy that I had in '07.  Well, I feel very similar.
Hubby drove me to ER and over the course of about 3 hours, my symptoms improved.  The fever went away and so did the itching.  ER doc told me to NOT take my dose of Plaq tonight, just in case I was having a reaction; and to phone my rheumy tomorrow morning. 
I still feel like total crap tonight.  The low-grade fever is back, it's stuck between 99.8 and 100.4.  Nausea, very sore muscles and an overall flu-like feeling is what I have right now.
I know that my symptoms could actually be my Lupus.  I guess I'm feeling more vulnerable because the medication allergy possibility is something I've dealt with before. My Lupus has been very quiet for quite some time now. 
Has anyone else experienced these sort of symptoms starting on Plaquenil?  Oh, I've been on it for 2 weeks now.
Thanks everyone
I can do anything through Jesus Christ who strengthens me. I have learned in whatever state I am in to be content. Phillipians 4:11-13
35 years old. Diagnosed with Lupus in 2000. Fibromyalgia, Anti-phospholipid syndrome(APS)(stroke, 2002), Sjogren's, Raynaud's, Libman Sach's Endocarditis, vasculitis, sacroiliitis, arthritis (neck), anxiety, PTSD. Prednisone, Imuran, Plaqunil, Coumadin, Clobazam, Amitriptyline, Didrocal, Cozaar, Zoloft, calcium, multi-vitamin, vitamin D, Magnesium, vitamin B6,
 Moderator for the Lupus and Fibromyalgia forums

Regular Member

Date Joined Jan 2008
Total Posts : 159
   Posted 8/30/2009 8:14 PM (GMT -6)   
absolutely, I was on it for 2 wks. and broke out in a horrid rash all over and explosive diarreha, I don't know if i had the fever as i never know when i do. but the nausea and achiness too. My doc took me off of it and i will be starting something else next visit. For now i was put on Prednisone and Lyrica.. I do hope you feel better. This is so horrible to get on and off meds.. good luck sweetie :-)
Cervical spine surgery 2004, C-section 1986, Cholecystectomy 1999, Thoracic and Lumbar injury 2000. Anxiety/depression 2008. Fibromyalgia 2009, Thyroidectomy 2008. Degenerative disc disease. IBS. Asthma, Rheumitoid Arthritis, Sacroillitis, Scolylosis, disc bulge in L5/S1.possible ankylosing spondylitis. Meds: Lisinophil, xoponex, symbocort, pulmocort, troponal, vitamin 2000 D, Vitamin B complex, Hydrocodone, Tylonal Arthritis, Cymbalta.prednisone and Lyrica

Veteran Member

Date Joined Jul 2009
Total Posts : 4796
   Posted 8/30/2009 8:41 PM (GMT -6)   
Hi Ginny.

Sorry to hear the plaquenil is still making you so ill. I was only on plaquenil for 9 months.
and never had any bad side effects. My rheumy took me off to put me on methotrexate.

Prayers are on the way for a speedy recovery. Hope you are able to get a good night's
sleep. Keep us posted.

 possible MCTD, Raynauds, Fibromyalgia, Osteoporosis, Degenerative
 Disc Disease, Osteoarthritis, High Blood Pressure, Migranes and
 Pseudothrombocytopenia, biopsy shows a Scleroderma variant
 MEDS: Methotrexate, Savella, Boniva,Lisinopril, Folic Acid, Flexeril, and
 Vitamin Supplements

Veteran Member

Date Joined Oct 2004
Total Posts : 2244
   Posted 8/30/2009 8:59 PM (GMT -6)   
Hi Ginny,

I am sorry to hear you have been so sick! I really hope your rheumy will have some suggestions tomorrow. Until then, take good care of yourself! Hugs
Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Lupus, Sjogrens, Raynaud's, Hashimoto's and Celiac Disease
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Folgard OS (B12), Vitamin D-50,000 IU, Tramadol (as needed) and magic mouthwash (for mouth sores)

Veteran Member

Date Joined Jun 2008
Total Posts : 1470
   Posted 8/31/2009 12:20 PM (GMT -6)   
Hey Ginny! I am so sorry. What did your doc think? Are you gonna stay on it or try something else? Do you know what the next step is if the plaquenil doesnt work out?
Do you know if your platlets have improved since you have been off the Imuran?( I think it was imuran)



Systemic Lupus , lupus nephritis , and a lot of other stuff associated with Lupus!

Cytoxan, Prednisone, Lupron, Zofran, Mesna, Lisinopril,  Ambien, Flexeril, Ultram, Darvocet, Ferrious Sulfade, Calcium, Vitamin B12, Aspirin 81 mg, Vitamin C

The Old Normal is no more so I and we have to find a New Normal...


Regular Member

Date Joined Mar 2009
Total Posts : 48
   Posted 8/31/2009 7:01 PM (GMT -6)   
Hey Ginny,

I have anew rheumy and he started me on plaquenil about two weeks ago as well. I have the nausea, diarhea, stomach cramps, I got a rash across the lower part of my back and a dry patch there as well. My scalp for some reason is itchy as hell. I had strept throat abut 3 weeks ago that came back last week. I was walking around with a fever, a little delirious and throat was so swollen I couldn't swallow. PCP said that the plaquenil makes you more prone to infection. But, I'm not feeling as fatiqued, but still very tired.

Veteran Member

Date Joined Sep 2005
Total Posts : 2573
   Posted 9/2/2009 12:20 AM (GMT -6)   
Ginny are you doing any better?
Dx:fibromyalgia 2002, systematic lupus 2005- definate CNS involvement dxed late 2005, psoriasis 2006, rheumatoid arthritis 2006, PTSD 2007, multiple allergies 2005, migraine, compression fractures T11 & T12, Sj√∂gren's, damaged periphrial nerves 2007, exema
Tx: plaquenil, Enbrel, Tramadol, Singulair, Skelaxin, Baby Asprin, Imuran, Prilosec, lasix, Evoxac, Celebrex, Darvocet when things get too bad, prednisone again, various vitamin/mineral supplements, cozar

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