blood blisters in mouth

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Veteran Member

Date Joined Sep 2005
Total Posts : 1744
   Posted 9/8/2009 12:31 PM (GMT -6)   
For all of you methotrexate users, I understand you can get oral ulcers from mtx (which is why we are instructed to take folic acid), but can you get blood blisters as well?  I had a huge blood blister on the inside of my cheek. Didn't hurt, and eventually popped just because of where it was--now I have a large black spot where the blister was.  Just wondering if it was related to mtx, and if I should increase my folic acid.  I've never experienced oral uclers from mtx (which are usually white and clear).
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Lupus
Current Meds: Enbrel, Methotrexate, nexium, tramadol, nasonex, Nifedipine, Folic Acid, Tylenol PM

Veteran Member

Date Joined Jan 2005
Total Posts : 659
   Posted 9/9/2009 9:03 PM (GMT -6)   
I get oral blisters and blood blisters in my mouth all the time and I don't take methotrexate. Perhaps someone else can tell you more but obviously mine are just another lupus thing.
DX: Nephrotic Syndrome, Membranous Nephropathy (? Lupus Nephritis) 2002
DX: Raynaud's Phenomenon and Lupus (SLE & Class V Lupus Nephritis) 2005
DX: Anorexia and Hypokalemia 2006
DX: Hpercalcemia, Hyperparathyroidism, Gout 2009

Veteran Member

Date Joined Dec 2005
Total Posts : 1950
   Posted 9/11/2009 11:42 PM (GMT -6)   
Hi, my son got them and they were horribly frightening to look at, he had them all over. The family doc looked at them and called them apthous ulcers (canker sores)even with the blood inside them, and gave him steroid dental cream (dental triamcinolone) to put on them, and the old miracle mouthwash. It took him a good month to get rid of them all. MY son's blood runs a little odd and perhaps that explains the blood blister appearance. His cbc is seldom perfectly normal. He has epilepsy and takes medicine.

The family doc or ear nose and throat or rheumie should help. The rheumie migth be the best as there are some other autoimmune diseases like Behcets and another one that tends to occur after an infection (I forget the name of it) and they also produce that type of mouth sore. I also believe some kinds of common infections can do that too.

I would get to the doc and get it treated as they can take a long time to get better and you don't want them to get worse.

I hope you feel better soon. The steroid cream and miracle mouthwash helped my son the most. They may have given him some pill medication too, I don't remember.
Love, Marji
Ills--Sjogrens-Lupus cond., AI polygland. dysfunction 2, hyper/hypopigment, scoliosis,kyphosis,stenosis, deg.,O.A.,spine surgeries, salivary/lymphectomies, NASH, COPD, RLS, UT/GI bleeds, hystero, brain/nerve damage,TB
Meds--INH,Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, HRT and Lidocaine patchs, Voltaren gel, Klonopin, Vicodin, Restasis, Albuterol, steroids

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