MCTD questions

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New Member

Date Joined Feb 2010
Total Posts : 2
   Posted 2/10/2010 4:11 PM (GMT -6)   
Hi, I had my first appointment with a rheumatologist (was referred to her due to positive ANA, fatigue and joint pain). She ordered more bloodwork for me to get a more specific look at what was happening. My bloodwoork came back with positive (HIGH) anti-RNP. I haven't seen her yet to discuss these findings, but from what I know, this is indicative of mixed connective tissue disease.

This seems to fit all my symptoms: fatigue, transient joint and muscle pain (and weakness), rashes (malar and upper chest and arms), sporadic low-grade fever, and strange hand and feet symptoms that, from what research I've done, appears to be Raynaud's coupled with erythromelalgia.

The curious thing and what I am seeking answers about is that I am currently having pain, rashes and low grade fevers, yet my sed rate and CRP were both normal. How does this make sense? How can I have genuine signs of inflammation (hands swell with erythomelalgia symptoms) and minor joint swelling, yet both tried and true tests to measure inflammation came back normal.

Can you have activity without any serological fluxuation? Will my doctor still be willing to prescribe medications to treat my current symptoms without these markers being elevated?

Thanks for any answers!

Veteran Member

Date Joined Sep 2005
Total Posts : 2573
   Posted 2/10/2010 4:42 PM (GMT -6)   
I have all labs completely normal, when my hands were so swollen and red that it looked almost like I had claws for hands the crp and sed were normal. If your doctor is good then she will treat regardless of blood work as long as you have symptoms. I really wish you luck.
Dx:fibromyalgia 2002, systematic lupus 2005- definate CNS involvement dxed late 2005, psoriasis 2006, rheumatoid arthritis 2006, PTSD 2007, multiple allergies 2005, migraine, compression fractures T11 & T12, Sj√∂gren's, damaged periphrial nerves 2007, exema
Tx: plaquenil, Enbrel, Tramadol, Singulair, Skelaxin, Baby Asprin, Imuran, Prilosec, lasix, Evoxac, Celebrex, Darvocet when things get too bad, prednisone again, various vitamin/mineral supplements, cozar
"Those who dream by night in the dusty recesses of their minds wake in the day to find that it was vanity: but the dreamers of the day are dangerous men, for they may act their dreams with open eyes, to make it possible." T. E. Lawrence

Veteran Member

Date Joined Apr 2006
Total Posts : 1344
   Posted 2/10/2010 8:17 PM (GMT -6)   
You can have negative labs for cpk, sed and aldolase but have an active disease state.  Eventually your labs will reflect your condition.
MCTD (lupus, scleroderma, polymyositis).  Diagnosed 2005.  Kidney, liver, GI tract, dysphagia, raynauds, Barretts esophagus, quadriplegic in 2005.  Recovered and now active in skiing, tai, chi, hiking, golf.  Meds: prednisone 2.5mg, imuran 25mg, amlodipine, benazapril, omeprazole, potassium, folic acid, vitamins, maxide and various supplements and vitamins.
Remain optimistic and you can overcome the odds.

New Member

Date Joined Feb 2010
Total Posts : 2
   Posted 2/10/2010 8:31 PM (GMT -6)   
Thank you both! I'm hoping my rheumy knows as much as some patients and prescribe something helpful. I've been trying other lifestyle changes to help alleviate symptoms, but nothing's helped so far, so I appreciate this news.
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