I've been taking MTX at the full dosage for several years now. However, when I first started (the first month) I basically felt as if I had the flu! I had terrible body aches and a few hours after my dose I literallly could not stay awake. I did adjust to the MTX and was told to take the folic acid daily, however initially it wasn't enough, and the fatigue from the MTX was overwhelming to the point I had difficulty getting out of bed. My doctor then prescribed Leucovorin (sp?) and it helped so much! I take it for my RA and it does wonders for my hip pain, and it also keeps my skin nice and clear. Please make sure you drink plenty of water!!!!!!!!! Good luck, I hope it works for you.