Complement C4 ?

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Date Joined May 2005
Total Posts : 7723
   Posted 7/9/2010 3:06 PM (GMT -6)   
I'm so confused!

My latest lab tests (3 pages of results) show that everything is perfect *except*

Complement C4 (serum) results, which are 43 mg/dL with normal being 9 - 36

I've looked this up every which way, and I find lots of results for what it means to have LOW C4, but only 1 result for HIGH C4. What I've found says this indicates active inflammation.

My questions:

1) Is this the same meaning everyone else has found? High C4 means inflammation?

2) How could this one test indicate inflammation when the results of the extended CBC seemed normal? (Oops, on second glance I see Neutrophils were at 72%, so high in normal range.)

Lynnwood, Lupus & Sjogren's Moderator
"Life is far too important to be taken seriously" - Oscar Wilde

Veteran Member

Date Joined Jun 2008
Total Posts : 1470
   Posted 7/9/2010 3:31 PM (GMT -6)   
Wow, that is unusual with Lupus, generally the C3 and C4 run low. I do know that high complement could possibly be an infection somewhere in your body...

On all my CBC's almost everything is normal but all my inflamtion markers and tests to check lupus activity are always high or low depending on the tests.

I think it would deffinatly be a great question to ask your doc next time you see him/her and let us know what they say :)!
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