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Regular Member

Date Joined Jan 2010
Total Posts : 45
   Posted 9/8/2010 9:20 AM (GMT -6)   
Just wondering if anybody out there had a negative ANA but still has lupus? I found out my ANA was negative so was wondering if lupus could be ruled out? Also wanted to add that it was 1:40

Post Edited (jackie81) : 9/8/2010 8:24:14 AM (GMT-6)

Regular Member

Date Joined Dec 2009
Total Posts : 34
   Posted 9/8/2010 9:29 AM (GMT -6)   
Hi Jackie81!
 My ANA has been negative and positive for years, one of the reasons why it took years for them to diagnose me. I don't know why it does this, or how it can even be possible (asked my doctor but he really didn't have an answer either tongue ).  I do know, after doing tons of research, that 5% of people can have a negative ANA test and still have Lupus. 
Diagnosed in 2008. Rheumatoid Arthritis, SLE, Dermatomyositis, Optic Neuritis. Medications; Prednisone 5mg a day. Methotextrate injections once a week.

Veteran Member

Date Joined May 2005
Total Posts : 7723
   Posted 9/8/2010 11:40 AM (GMT -6)   
A negative ANA has no ratio to report. Some doctors consider a low positive ANA such as 1:40 same as a negative.

Yes, you can have a negative ANA and still have lupus. Check the website for "How to diagnosis lupus" - you have to have 4 of 11 symptoms.

Lynnwood, Lupus & Sjogren's Moderator
"Life is far too important to be taken seriously" - Oscar Wilde

Veteran Member

Date Joined Sep 2005
Total Posts : 2573
   Posted 9/8/2010 2:25 PM (GMT -6)   
I am one of those negative ANA lupus suffers. Take a look at my signature and know that except for a high white cell count all my blood work is normal.
Dx:fibromyalgia 2002, systematic lupus 2005- definate CNS involvement dxed late 2005, psoriasis 2006, rheumatoid arthritis 2006, PTSD 2007, multiple allergies 2005, migraine, compression fractures T11 & T12, Sjögren's, damaged periphrial nerves 2007, exema
Tx: plaquenil, Enbrel, Tramadol, Singulair, Skelaxin, Baby Asprin, Imuran, Prilosec, lasix, Evoxac, Celebrex, Vicodine when things get too bad, prednisone again, various vitamin/mineral supplements, cozar, duragesic patches
"Those who dream by night in the dusty recesses of their minds wake in the day to find that it was vanity: but the dreamers of the day are dangerous men, for they may act their dreams with open eyes, to make it possible." T. E. Lawrence

Regular Member

Date Joined Jul 2010
Total Posts : 468
   Posted 9/8/2010 3:01 PM (GMT -6)   
I just saw your post and it reminded me of a reply I posted to someone regarding ANA the other day. I am too lazy to type it out again lol so I will  just paste my reply here:

My ana was 1:160 and it was enough to gain attention from my DR ( that was 4 years ago). I recently met with my DR and he actually told me that many docs do not take ANA into consideration when diagnosing Lupus because ANA is so unreliable. He said that it can change (go from pos to neg) he said he treats patients usually based on past ANA test and also current symptoms that they have.


Hope that helps.


Regular Member

Date Joined Feb 2010
Total Posts : 138
   Posted 9/8/2010 3:49 PM (GMT -6)   
Me too my test went from posative to negative now posative again. I have lot's of symptoms but none of my other test are posative either so we hang in limbo
Cymbalta,tramadol,tylonol 4, nexium,verapamil,325 mils of asprin,multi vit,duloxetine hcl,vit D,vit b-6, and simvastatin

High blood pressure,high cholesterol, Carpel tunnel synd,acid reflux,insomnia,fibromialgia, High ANA possibliy Lupus ( no diagnoses) Vitamin D defficient, arthritis in most of my joints.
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