My ANA has been negative and positive for years, one of the reasons why it took years for them to diagnose me. I don't know why it does this, or how it can even be possible (asked my doctor but he really didn't have an answer either ). I do know, after doing tons of research, that 5% of people can have a negative ANA test and still have Lupus.
Diagnosed in 2008. Rheumatoid Arthritis, SLE, Dermatomyositis, Optic Neuritis. Medications; Prednisone 5mg a day. Methotextrate injections once a week.