Imuran and weight effects

Imuran weight gain?
Yes - 0.0%
No - 100.0%

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Regular Member

Date Joined Sep 2010
Total Posts : 24
   Posted 9/21/2010 8:26 PM (GMT -6)   
Hey Everyone... I am new to the site, but I've read some things on here before and always enjoy reading everyone's experiences; which many times have been my own and have been very helpful to me. So I thought it was time for me to contribute some of my own as well as start interacting with people that know what its like living with lupus. I am going on 2.5 years with my diagnosis. I am a fresh 25 year old female (just turned 5 days ago) and have had many ups and downs with this illness. I also have psoriasis :-(, its under control but it is hard to cope with. Although my psoriasis is mild with i am grateful for it still makes me stressed. I went from a super healthy 21 year old to a now struggling 25 year old in a matter of days sort of say. Any how about my topic... I have recently gone to see a new rheumatologist in the NYU Hospital for Joint Disease in nyc. I am very excited about the new doctor, they are very involved and listen to all your concerns and use your input in the treatment. I am currently on Plaquenil 400mg daily and also use Naproxen 500mg daily for inflammation. My inflammation in my hands has been increasingly painful the past three months. My DR. has brought up a new medication idea and I wanted to get some input if anyone here has had any results with or any side effects or concerns or the medication Imuran. I am mainly concerned about weight gain. I have researched and none of the side effects say weight gain but neither did the ones from Methotriexate but have read many testimonials that say they have had many weight gain from Methotriexate.... Please let me know if anyone has had any experience with Imuran.... Thank you! :-)

Veteran Member

Date Joined Feb 2003
Total Posts : 5514
   Posted 9/21/2010 9:42 PM (GMT -6)   
Hi Shinylight,
Welcome to the forum. I've been on Imuran for 10 years.  From the very first day of my diagnosis.  It's been a very good immune suppressant for me. I have had no weight gain issues with it at all.  I had a little bit of hair loss at first, but that rectified itself.  You might experience some tummy discomfort for the first 2 or 3 weeks until your body gets used to it.  I took my pills with supper, so that helped a lot.  It can affect your liver by increasing some of the specific enzymes.  So you'll have to get your blood checked monthly to monitor that.  Overall, it's worked great for me.  I hope you have the same good luck!!
Moderator of Lupus and Fibromyalgia forums

36 years old, diagnosed in 2000. SLE, Fibromyalgia, APS, Sjogrens, Raynauds, Thrombocytopenia, Vasculitis, Stroke – 2002, Bilateral sacroilitis, Clinical Depression/PTSD/Anxiety/panic disorder, Optic Neuritis. Prednisone, Imuran, Plaquenil, Coumadin, Cozaar, Zoloft, Didrocal, Seroquel

Regular Member

Date Joined Sep 2010
Total Posts : 24
   Posted 9/21/2010 10:41 PM (GMT -6)   
Thank you so much for your input, I really appreciate it. I see you have a lot of years with the condition and makes me feel at ease that I get the opinion from people that have actually used the medication and not just from research and doctors that state things. Thank you! :-)

Veteran Member

Date Joined Sep 2005
Total Posts : 2573
   Posted 9/21/2010 11:07 PM (GMT -6)   
I have been on imuran for a while and no weight gain despite being on high doses. I have had some liver enzyme issues and have to d/c for a week but otherwise am doing fine with it.

Veteran Member

Date Joined Jun 2008
Total Posts : 1470
   Posted 9/22/2010 7:00 AM (GMT -6)   
I used Imuran at the highest dose for 2 years and had no weight gain. It didnt help at all but I hear it works great for many people! Good luck with it and to be 100% honest, don't worry about the weight gain, i know you are young...I am 23 myself. Your biggest concern should be keeping or getting your lupus in control and laying low. If you do gain weight, once your lupus quits down then you can work on the weight loss. I gained 80 pds from medicine but if it wasnt for prednisone, I would be dead right now. Yeah, the weight stinks but i think I would rather be alive than the alternative on most days.
Kidney Diseases & Disorders and Lupus Moderater
Cyclosporine, Prednisone, Lisinopril, Integra Plus, Vitamin D 50,000 units
PRN: Imitrex, hydrocodone, Ambien, Flexeril, Ultram, Darvocet, Zofran

If God brings you to it, he will get you through it!!
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