So sorry you are not feeling well. How long have you been on the plaquinel? It is a really good drug for getting the disease under control but it sometimes takes months before you really feel the effects. That's why they have you on the prednisone for the inflammation. 50 mg is a pretty high dose so you must be in alot of discomfort. I don't know alot about the dmard drug Imuran but I assume that will also take a little while to take effect. Make sure you get plenty of rest. Autoimmune diseases are different for everyone here. What kind of tests have you had done? I'm assuming that with the drugs they put you on they have received results that indicate autoimmune issues. Hang in there, it will get better.
Hugs and Angels,
DX - sle and carpal tunnel
RX - plaquenil, prednisone, lisiniprol, etolodac, folic acid, cenestin and prometrium, darvocet and flexeril when needed and daily vitamins