In 2003 I had a sonogram and MRI and I was told my spleen was moderately enlarged, well then in 2009 I had a sonogram and the hematologist said it was not enlarged ( different hematologist). But something is bothering me on the left side of my abdomen below my ribs. Some days when I'm really tired I have pain in that area (or the pain makes me really tired, haven't figured out which way that works) and it can be so bad that I just have to stop and lay down. Sometimes I chalk it up to gas and my NP did say something about the majority of the large intestine, i forget what she called it, is on the left side so it's possible to have gas pain just on the left side. It's usually days that I have had to just go and go all day. And then some days like today I can feel pressure and discomfort in that spot, it's hard to describe, I don't know if pressure is the right word it's kind of like i'm running out of room. if I try and lay on my right side I get a sensation from the left like something is pulling or not supported or it puts pressure on my abdomen and I have to turn onto my left side and then I'm ok. I'm really having a lot discomfort in that area today. and the pressure has gotten worse recently, yesterday I felt pressure all the way up into my left shoulder. Does anybody have an enlarged spleen or understand what I'm talking about?