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Regular Member

Date Joined Mar 2004
Total Posts : 97
   Posted 1/1/2011 8:51 PM (GMT -6)   
Hi all, My rheumatologist is now recommending that I switch from prednisone to methylprednisolone.

I've been having ongoing skin problems that don't seem to get better with increased dosages of prednisone, which has always worked for my different flareups in the past. So he wants to try something different.

Has anyone tried this drug before?


Regular Member

Date Joined Dec 2010
Total Posts : 62
   Posted 1/2/2011 12:35 AM (GMT -6)   
I was on Methylpred for 6 mo. 60mg per day for a month weaning down each month for a reation to Remecade. I had the moon face, 17 lb water gain, walking the floor at night, mood swings, I had it all. Each month down sizing, there were withdrawals from the high dose, terrible anxiety and depression. But I had no choice. The pain in all the joints, the swelling with skin peeling off from the reaction I just couldn't take. Percocets would just take the edge off, making it tolerable. I was taking careful precautions with the percocets so I wouldn't get tolerant to the med or addicted. As a result, I still have what they call migrating arthritis from the Crohn's.

Veteran Member

Date Joined Apr 2006
Total Posts : 1344
   Posted 1/2/2011 12:12 PM (GMT -6)   
Some people with lupus have absorption problems with oral meds and have to go to iv or injectable forms.  I took it for just such reasons during the first few months.  Essentially, it is prednisone and has the same benefits and side effects.

Veteran Member

Date Joined Jun 2008
Total Posts : 1470
   Posted 1/3/2011 6:52 AM (GMT -6)   
I have been on this many times!! I have been told by the nurses that do the injection that this is a tad stronger form of prednisone! If your doctor would like to switch to it, I would probably go with his/her suggestions!! If you do decided to switch I hope you will see results from it :)
Kidney Diseases & Disorders and Lupus Moderater
Cyclosporine, Prednisone, Lisinopril, Mobic, Vitamin D 50,000 units
PRN: Imitrex, hydrocodone, Ambien, Flexeril, Ultram,

If God brings you to it, he will get you through it!!

Regular Member

Date Joined Jan 2011
Total Posts : 82
   Posted 1/3/2011 2:33 PM (GMT -6)   
I get intramuscular injections of methylprednisolone for flares, it is a slightly different form of steroid. I like it waaaayyy better than oral prednisone!! For me, it gives me hardly any side effects (compared to oral prednisone, which made me RAVENOUS, bloated, and unable to sleep), and as a plus you don't have to keep track of tapering doses.


Regular Member

Date Joined Mar 2004
Total Posts : 97
   Posted 1/5/2011 12:14 PM (GMT -6)   
Amy - good to know it's a bit stronger than prednisone. I was at 10 mg of pred, and the Methylprednisolone pills come in dosages of 4mg each, so I'm taking 8mg - now that I know that this drug is a bit stronger, I'm not worried about reducing my intake (I'm trying to taper down, anyway, though maybe that's not the best idea, as I may be flaring! We'll see what happens in the next couple of weeks, and what the bloods show.)

Kathryn & Bill - It's interesting to know about the injectable form. I am actually taking a pill form - but if this doesn't improve things, and the skin rash remains as my only symptom of a flare, I'll ask my rheumy about the injectable form.

Rojon - What you describe sounds exactly the same as what one experiences with prednisone! It's all familiar territory.

Thanks all for the information - very helpful.
Diagnosed: Sjogren's '94, Raynauds 2000, Vasculitis 2002, Lupus SLE 2004, Lupus Nephritis 2007 (Kidneys are healthy now)
Meds: Cellcept (1000 - 1500 mg), Hydroxy-chloroquine (400 mg), Prednisone (10-15 mg), Atenolol (50 mg), Enalapril (20 mg). Vitamins/Minerals include: Multi Vitamin, Calcium. Other Supplements include: DHEA, Quercetin, Astragalus
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