Prednisone NOT working....??

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MissLadybug
Regular Member


Date Joined Oct 2008
Total Posts : 261
   Posted 4/27/2011 1:30 PM (GMT -6)   
Hello all. I went to the er this past friday night for pain upon breathing. It ended up being pleurisy again. They gave me a prescrip for Naprosyn & Prednisone(60mgs once a day for 5 days)...I emailed my rheumy since I hadnt heard from her since telling her about my original symptoms.(she was going to do a short term prednisone treatment anyway)..she said 60mgs was way too much & called in some 5mg tablets so I could start 20mgs for a week then taper off dropping 5mgs each week till I was done. I took 60mgs 2 days in a row before I heard back from her to hopefully get some relief. Well,the pleurisy is better but the aching/burning in my joints is not. Im also still getting rashes & its making me sleepy. I have heard prednisone can do the opposite. When I told my rheumy how Im feeling she said its probably because it`s not inflammatory that im experiencing?!...or that its still early in the prednisone treatment...I just feel like it hasnt done anything for me...am I expecting too much? Does it really not work for some people by itself?...please Id love to hear stories from everyone! Side effects,etc. Thanks so much. Hope I find you all well. *hugs* -Lupie Britt aka LadyBug

Note: I am taking only one dose of the recommended amount each day, not spreading it out over the course of a day..should I spread them out??

NikiS
Regular Member


Date Joined Mar 2011
Total Posts : 129
   Posted 4/27/2011 4:11 PM (GMT -6)   
Hi! I found that it took longer for Prednisone (at 10 mg) to start working for me when my doctor put me on it this week... I had had 2 solumedrol shots within about a week which had given me faster relief (within maybe 5-6 hours both times) and had worked better on the medrol 4 mg pack I took. Maybe your rheumy might consider another steroid or maybe if you give it just another day or two? I am on my 3rd day now and still not quite feeling as better as the medrol had helped, but it is still more relief than I had without any steroids so I am grateful for them. I don't know if that helps you or not... I have not been diagnosed with Lupus and see my rheumy for the 1st time next wed... Good luck, Nicki!

panther fern
Regular Member


Date Joined Feb 2011
Total Posts : 163
   Posted 4/28/2011 1:44 AM (GMT -6)   
When i get infusions once a month when i am in a flare i get solumedrol shots usually 80 mg and it helps esp until the full affect of the infusion kicks in. I try to stay off prendisone because i don't notice it being beneficial enough, and it makes my sugar really high (diabetic) I would say at 60 mg you should be feeling no joint pain after a day or two, I would call my dr. and say I am just not feeling right.. I wouldn't spread them out.. My rheumy told me when i do medrol packs or stuff like that to take all at once in the am. because steriods usually make you awake . I would call your dr. leave a message with phone nurse say your breathing easier but you just are not feeling well your joints are killing you and your rashes are present and you just don't feel right, should you wait it out or come in?

hope you feel better soon.

MissLadybug
Regular Member


Date Joined Oct 2008
Total Posts : 261
   Posted 5/13/2011 10:20 PM (GMT -6)   
Hey all. I am still currently on the prednisone...started with the 60mgs for 3 days..then dropped to 20mgs for a week then the 10mgs. I will be on that for 2 weeks instead of one and then lower by 1mg every 2 weeks until i'm off...however 2 days ago I didn't get much sleep and it was the same last night...so I'm not sure if that's why but my symptoms are coming back..more so today than yesterday which is why I didn't say much to my rheumy cuz all I really had was a mouth ulcer but she knew that. I am 3 1/2 hrs from her and she sent me home with the prednisone prescrip for more and bloodwork but said not to get it done till june since I just got results back this week from some that was done late last month. I feel like I am flaring all over again ehhhhh
My rheumy also said that if I have to use prednisone twice or more in a year then she will want to try Methotrexate...if that ends up not working then she said I would be a good candidate for Benlysta....anyone taken this? I know it is new and is an infusion drug....hope you all are feeling better than I am!
*Lupie Britt*- Epilepsy Dx: 2003 & UCTD w/SLE features Dx: 2009--Current Meds:Plaquenil-200mg 2x/day, Keppra-750mg 2x/day, Prenatal Vitamin- 1 pill/day, Folic Acid- 1mg 1x/day, Prilosec 20mg 1x/day, Colace 1x/day, Vitamin D- 800IU's 1x/day

*Forever_His_LadyBug**I <3 Mr. Officer, cookie Monster, Thing 1 & Thing 2** xoxoxoxoxo You all are my life and I am eternally greatful!

Bsime
Veteran Member


Date Joined Apr 2006
Total Posts : 1344
   Posted 5/15/2011 10:50 AM (GMT -6)   
Short term treatments usually do not work.  Effective treatment is usually very long term starting with a higher dose and slowly tapering to a maintenance dose.  A second drug that is not prednisone is usually added to provide a controlling med that is better tolerated than pred over the long term.  Treating lupus is not like treating an infection.  Treatment suppresses a misdirected immune system which will sometimes reset itself over a long period of time and go into remission but you cannot count on that happening.
 
I would seek a second opinion from an experienced rheumy about your treatment.  Never heard that short term treatments work except temporarily.  Many of us have been on pred for years.....6 years in my case but will be off soon.  Also had IVIG and imuran along the way.
 
Every patient responds differently to treatment and what works for one might not for another. 
 
Bill

MissLadybug
Regular Member


Date Joined Oct 2008
Total Posts : 261
   Posted 5/16/2011 10:47 AM (GMT -6)   
Thanks Bill for the response. I honestly didn't expect a relief tapering down this quickly. My rheumy is just finishing up her fellowship program at Johns Hopkins University in Baltimore, MD but she is overseen by other more experienced rheumatologists...so you would think that they would know what to do....maybe they just give her too much say in the matter i don't know...I will see what she has to say when she writes back to my email...hopefully I'll hear from her today since it's the start of a new week. Thanks again and I'll repost when I hear something!

...She did mention if prednisone didn't work by itself we could try Methotrexate, Cellcept or Imuran and then if that wasn't sufficient the Benlysta infusions...maybe something will work...let's hope! -Brittanee
*Lupie Britt*- Epilepsy Dx: 2003 & UCTD w/SLE features Dx: 2009 SLE/Lupus Dx: May 12th 2011--Current Meds:Plaquenil-200mg 2x/day, Prednisone-10mgs taper 1mg every 2 wks, Keppra-750mg 2x/day, Prenatal Vitamin- 1 pill/day, Folic Acid- 1mg 1x/day, Prilosec 20mg 1x/day,Vit. D 800IU's 1x/day, Allegra 180mg 1x/day, Flonase 50mcg 2 sprays each 1x/day.

*Forever_His_LadyBug**I

Bsime
Veteran Member


Date Joined Apr 2006
Total Posts : 1344
   Posted 5/16/2011 2:41 PM (GMT -6)   
Good luck.  The rheumatology dept. at JH is excellent and I know one of the docs and know others by reputation.  JH has the only Myositis (a class of muscle disease that I have) in the world and their docs are highly respected.
 
If you eventually go to Benlysta the approval process is not easy.  I have one friend on it and another trying to get approval.  
 
The short course treatments are common but I have yet to hear they work.  It was tried with me several times but did not suppress my immune system and went on a long course of pred which did not work either.  Early and aggressive treatment is usually best but I think some docs are reluctant to be that aggressive until the symptoms worsen.  All the drugs have down sides and a conservative treatment is usually prescribed unless it is a really bad case.  Mine started out slowly and steadily got worse and then got a lot worse in the course of a week. 
 
Bill
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