Cognitive dysfunction is often part of a lupus flare. When mine was active, my doctor tried Imuran (did nothing for me), then Cellcept (worked miracles for me), and the next trial would have been MTX.
These are the top 3 meds that are usually brought into play when Plaquneil & Prednisone aren't improving our symptoms much. It's mix/match - they never know which med with work with with patient - so you may have to try 2 or 3 of these before you feel better.
The good news is lupus isn't always a "progressive" illness - my brain was so bad I could barley follow a 30 minute sitcom and didn't drive as I wouldn't be able to recognize my surroundings. Today I my comprehension and concentration are pretty much normal! So it doesn't have to be a permanent condition.
Hope you feel better soon,
Lynnwood, Lupus & Sjogren's ModeratorDIAGNOSING-LUPUS & LUPUS-RESOURCES
"Life is far too important to be taken seriously" - Oscar Wilde