This is a very popular and normal combination, I'd say that at least 75% of the lupus forum members have been on it!
Plaquenil is an anti-malarial that slows the progression of the disease. Prednisone is a cortiocosteriod that manages inflammation. They have different jobs to do and don't interfere with each other.
Hope Mom feels better soon.
Lynnwood, Lupus & Sjogren's ModeratorDIAGNOSING-LUPUS & LUPUS-RESOURCES
"Life is far too important to be taken seriously" - Oscar Wilde