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elv
New Member


Date Joined Sep 2011
Total Posts : 2
   Posted 9/9/2011 4:58 PM (GMT -6)   
Hi all!
 
I'm new to the whole auto immune disease world. Last week I received a referral from my doctor to see a rheumatologist because I have a slightly high anti rnp level. Infact the test results on a negative scale of 0.0-0.9 was 1.1 so just slightly higher. Everything else was less than 0.2 and other blood tests came back normal. I do not have any symptoms. The reason my dr ordered the test was that I was having fast heart rate randomly. I've been checked out by a cardiologist and all the tests seem to be normal and this could possibly be psvt.
 
A little history...
2009 I did get Lyme disease. It took about a month and half for symptoms to show up (mainly fatigue) and then I was put on anitbiotics which took care of it. I think the only remaining symptom I had with that was achy feet but I have done research and that could take a while to subside. My feet only hurt when I'm on them all the time.
Most mornings when I wake up, my fingers are slightly swollen but the swelling subsides. I have absolutely no pain. I do have highly sensitive skin which I've had for about 10 years now so I have to be careful about soaps and lotion.
 
Could this be a false positive? has anybody experienced a similar situation? I see the rheumy next week. ANy insight would be greatly appreciated. Thanks

jeanneac
Veteran Member


Date Joined Feb 2009
Total Posts : 1914
   Posted 9/9/2011 5:57 PM (GMT -6)   
What is an rnp??? If you aren't having any symptoms and one test is slightly elevated, most docs don't worry about it. Perhaps the rheumy will have some thoughts for you. Good luck. Keep everyone posted.
d 1/09 with colitis sigmoid colon with some diverticular disease as well, Colon resection Nov. 2010, now in remission!
inflammator arthritis, type 2 d, asthma, skin scleroderma, VSL#3 probiotic, Vit. D, nexium, synthroid, plaquenil, lactose intolerant, benicar
Blood test positive for Crohn's via prometheus ibd serology panel ASCA. Positive ANA speckled pattern 1:180, high sed r

Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 7720
   Posted 9/9/2011 6:21 PM (GMT -6)   
We can't really help diagnose you. Please keep your appointment with the rheumotologist and answer the questions they'll ask. They are the guys with the knowledge about auto-immune diseases, and will help you figure out if this is something that you might want to take preventative action against or if the things bothering you are totally not related.
Lynnwood, Lupus & Sjogren's Moderator
DIAGNOSING-LUPUS & LUPUS-RESOURCES
"Life is far too important to be taken seriously" - Oscar Wilde

elv
New Member


Date Joined Sep 2011
Total Posts : 2
   Posted 9/10/2011 8:39 AM (GMT -6)   
thanks for the reply. :-)
I do understand that you can not provide a diagnosis. I was just wondering if anyone had a similar situation where their ANA's - particularly the rnp antibody- were slightly positive and if it ever amounted to anything and if it did how long did it take for symptoms to appear. Such as were they gradual, drastic, etc. I also understand that autoimmune diseases affect everyone differently ranging from very mild to very serious and not everyone has the same symptoms.
 
RNP is the RNP antibody which is connected to mixed connective tissue disease which could include Lupus, scleroderma and polymytosis (I believe I spelled those correctly). I've found information about mctd but I have been unable to find anything regarding slightly elevated ana's.
 
So far what I have been able to find is that most people who are diagnosed with mctd have had symptoms for a while or more pronounced symptoms.
 
 

Post Edited (elv) : 9/10/2011 8:43:43 AM (GMT-6)


Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 7720
   Posted 9/10/2011 9:23 AM (GMT -6)   
Sometimes it just really varies -- what can be a mild irritation to one person can be a big deal to another. When the Dr asks detailed questions often things come up that we never would have considered to be part of the equation.

Some Dr's want to take some preventative measures when tests are low or inconclusive, some are more cautious in their approach. It just varies so much that anything we say is just a stab in the dark! Some dx using only bloodwork, some will dx based on symptoms without bloodwork, some require both be present. These auto-immune diseases are impossible to dx based on just one discrete thing...they are much more sneaky!

I would recommend that you don't try to self-diagnosis based on a single blood test. Rheumy's are equipped to understand the test in light of everything else going on with you....everything from weight to amount of stress to how often you get headaches to...who knows? Maybe those achy feet have to do with weak muscles associated with something....it's all a big puzzle - Lupus is known as the disease with a 1000 faces as its so tricky to dx, and the other auto-immune diseases just as tricky.

A slightly elevated ANA can a false positive, or relate to some other kind of inflammation you might have....there are just so many possibilities. Try to stay in the moment and if you don't feel poorly then don't anticipate feeling poorly -- our minds do control some of our physical state!

Hang in there!
Lynnwood, Lupus & Sjogren's Moderator
DIAGNOSING-LUPUS & LUPUS-RESOURCES
"Life is far too important to be taken seriously" - Oscar Wilde

feta
New Member


Date Joined Nov 2011
Total Posts : 1
   Posted 11/30/2011 6:26 PM (GMT -6)   
Elv, I hope you're feeling well. I'm looking for some info on RNA results. My 4-yr old daughter was just tested for allergies and the allergist ran an ANA test and she turned up with an RNP of 1.1. we are seeing a rheumatologist next month. All her other labs are normal, including complement factors.
She's had eczema for years and just started to get hives following a virus. The hives are well controlled with zyrtec. We are confused because she's otherwise without any symptoms.
Did you get treatment for your 1.1 RNP and what did they tell you about disease progression, if any?

Bsime
Veteran Member


Date Joined Apr 2006
Total Posts : 1342
   Posted 11/30/2011 9:12 PM (GMT -6)   
Anti rnp positive results are usually associated with MCTD and sometimes lupus.  You need to discuss the results with a rheumy...one blood test does not a diagnosis make.  MCTD symptoms can include those from lupus, scleroderma and polymyositis.
 
 
Bill
MCTD (lupus, scleroderma, polymyositis).  Diagnosed 2005.  Kidney, liver, GI tract, dysphagia, raynauds, Barretts esophagus, quadriplegic in 2005.  Recovered and now active in skiing, tai, chi, hiking, golf.  Meds: prednisone 2.5mg, imuran 25mg, amlodipine, benazapril, omeprazole, potassium, folic acid, vitamins, maxide and various supplements and vitamins.
 
Remain optimistic and you can overcome the odds.

Grace Ann
New Member


Date Joined Nov 2012
Total Posts : 1
   Posted 11/2/2012 7:06 AM (GMT -6)   
Feta,

I was wondering if you have an update on your daughter's condition? I am in a similar situation. My 4 year old daughter has been seeing a dermatologist for hives. They recommended blood tests and everything was normal except her RNP was high, 1.9. She has no other symptoms. She has also been taking Zyrtec for the hives.

Thanks so much!
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