ANA 1:160 plus positive HLA B27

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The Professor
New Member

Date Joined Oct 2011
Total Posts : 2
   Posted 10/14/2011 12:07 PM (GMT -6)   

After 7 years of being told I might have lupus, rheumatoid arthritis, or AS, I saw a new rheumatologist who said I continue to have a positive ANA (it's been 1:160 for all 7 years no matter what) and a positive HLA B27. I've had multiple cases of uveitis over my lifetime and also have joint pain (severe in single joints), fatigue, and other vague symptoms.

So, I am a bit confused as my new doctor called me a lupus patient but all of my specific lupus tests came out negative. She said with ANA and HLA B27, I am definitely an autoimmune patient. Do many people test positive for both? Is there any way of knowing what this means in the long run since I don't seem to have the typical lupus symptoms of face rash, hair loss, etc. nor do I only have uveitis.


The Professor (and MaryAnne) that show

Veteran Member

Date Joined May 2005
Total Posts : 7723
   Posted 10/14/2011 12:52 PM (GMT -6)   
Check out the symptoms of lupus by following the Diagnosing Lupus link in my signature. Lupus is diagnosed by having 8 or 11 symptoms -- which may or may not include the facial rash and hair loss. (I have neither of those, but most definitively have had lupus since 2002.)

Actually, the biggest question is usually not so much what the diagnosis is, but are your symptoms being treated?? You don't *have* to have joint pain or fatgiue -- those were some of my initial symptoms and have been greatly lessened by treatment!

Hope you feel better soon,
Lynnwood, Lupus & Sjogren's Moderator
"Life is far too important to be taken seriously" - Oscar Wilde

The Professor
New Member

Date Joined Oct 2011
Total Posts : 2
   Posted 10/14/2011 1:46 PM (GMT -6)   

Thank you. I have 5 of the symptoms, so it isn't very helpful. My rheumatologist has me on methotrexate and folic acid. I've taken it before years ago, went off of it (I wasn't convinced anything was wrong with me) and then about two years later had serious episodes of uveitis and almost lost my vision entirely (both eyes). The metho is supposed to help the uveitis in particular, and hopefully the joint pain and inflammation as well.

I'm curious about the HLA B27 connection as this piece of info is new. Do lupus patients have this often? As I said, she called me a lupus patient but stated that I had more problems under the HLA gene.

Methotrexate is tough the second time around, BTW. Not sure why for me, but I am extra sick this time and lost my eyelashes.

New Member

Date Joined Oct 2011
Total Posts : 3
   Posted 10/25/2011 5:13 PM (GMT -6)   
It sounds more like ankylosing spondylitis. Have they ever mentioned this to you?
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