I've been on Plaquenil since 2007, 400 mg a day.
Although its a possibility, eye problems are rare from Plaquenil. That being said, my doc has had a case on another patient.
It's important to get a baseline prior to taking the med or very soon after starting it and when your ophthalmologist decides its best for you to come back for your regular checks, usually between 6-12 months.
It's a very common concern for people who begin this med, I think I was very concerned also when I began taking it.
DX:SLE, Sjogrens, Raynauds, Migraines, Occipital Neuralgia, Dysautonomia, Morphea (Localized Scleroderma), Iron Deficiency Anemia, IBS, Diverticulosis
Meds:Prednisone, Cellcept, Plaquenil, Sulindac, Tramadol, Topamax, Xanax, Imitrex, Fiorinal, Prenatal Multi, B12, Vit E, Calcium, Fish Oil, Biotin, Ferrous Gluconate, Baby Aspirin, Salt Tablets