Saw Rhuemy C4 Serum still low should I not be concerned?

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Regular Member

Date Joined Jul 2010
Total Posts : 468
   Posted 12/7/2011 11:14 AM (GMT -6)   
Hi everybody,
I saw my Rhuemy the other day to go over blood work. My Vit D is up but my C4 levels are low and have been for over 5 years now. I know low C4 shows active lupus from what I have read along with other issues but my Dr kind of just brushed it off and told me not to worry. Is it really not anything to be concerned about? From what I have read it doesnt seem like something that is just commonly low for people.  Im just nervous because its been low since about 20. What if it just keeps getting lower and lower? He wants me to continue with the Plaquinel. Also I have to make an appt with my PC because of pain I been having which could be a cyst. Besides that everything is ok.

Veteran Member

Date Joined May 2005
Total Posts : 7723
   Posted 12/7/2011 2:19 PM (GMT -6)   
According to my readings & experience with my doctors, just one component of the bloodwork being out-of-range (low or high, depending on what is being measured) doesn't necessarily mean action is needed.

Now if several components of the bloodwork are out-of-wack AND their is an increase in symptoms, that's when my doctors stand up and take notice and start talking about changing things!

Specifically about C4, my research found places that said "C4 is commonly low in Lupus patients" -- but nothing at all about that meaning Lupus is more active. My doctor relies more on the inflammation markers: Neutrophils, Lymphs, Monocytes, Eos, Baso; (along with symptoms) to indicate activity. And when I read my blood tests and compare them with how I feel -- well, generally the inflammation markers are correct!

So, in short, as long as you don't feel a lot different I wouldn't worry about it, esp. if the doctors aren't worried about it.

Hope you feel ok!
Lynnwood, Lupus & Sjogren's Moderator
"Life is far too important to be taken seriously" - Oscar Wilde

Regular Member

Date Joined Jul 2010
Total Posts : 468
   Posted 12/9/2011 12:53 PM (GMT -6)   
Thanks. I guess I was just worried that if it was already low at 20 that by the time I hit 40 I would be in major trouble but maybe thats not how it works. I even looked up other possible reasons it could be low but lupus is the only one that makes sense for me.
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